Evaluation of BBG2Na in infant macaques: specific immune responses after vaccination and RSV challenge

Leon de Waal; Ultan F Power; Selma Yüksel; Geert van Amerongen; Thien N Nguyen; Hubert G M Niesters; Rik L de Swart; Albert D M E Osterhaus

doi:10.1016/j.vaccine.2003.10.008

Evaluation of BBG2Na in infant macaques: specific immune responses after vaccination and RSV challenge

Leon de Waal, Ultan F Power, Selma Yüksel, Geert van Amerongen, Thien N Nguyen, Hubert G M Niesters, Rik L de Swart, Albert D M E Osterhaus

Research output: Contribution to journal › Article › Academic › peer-review

48 Citations (Scopus)

Abstract

We have addressed the safety of alum-adsorbed BBG2Na, a recombinant respiratory syncytial virus (RSV) subunit vaccine, in infant macaques. Animals received two vaccinations, and were challenged 4 months later with RSV. In two of four BBG2Na-vaccinated animals, specific IL-13 producing T cells were detected. Upon challenge, low level pulmonary eosinophilia was observed in the same two animals. Although the levels of these responses were substantially lower than those observed in the FI-RSV controls, these data suggest that more extensive studies focusing on immunopathological safety of alum-adsorbed BBG2Na in non-human primates would be required before proceeding to clinical trials in seronegative infants.

Original language	English
Pages (from-to)	915-22
Number of pages	8
Journal	Vaccine
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.vaccine.2003.10.008
Publication status	Published - 25-Feb-2004
Externally published	Yes

Keywords

Animals
Antibodies, Viral
Immunoglobulin G
Interleukin-13
Macaca fascicularis
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Vaccines
Respiratory Syncytial Viruses
Reverse Transcriptase Polymerase Chain Reaction
Time Factors
Vaccination

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title = "Evaluation of BBG2Na in infant macaques: specific immune responses after vaccination and RSV challenge",

abstract = "We have addressed the safety of alum-adsorbed BBG2Na, a recombinant respiratory syncytial virus (RSV) subunit vaccine, in infant macaques. Animals received two vaccinations, and were challenged 4 months later with RSV. In two of four BBG2Na-vaccinated animals, specific IL-13 producing T cells were detected. Upon challenge, low level pulmonary eosinophilia was observed in the same two animals. Although the levels of these responses were substantially lower than those observed in the FI-RSV controls, these data suggest that more extensive studies focusing on immunopathological safety of alum-adsorbed BBG2Na in non-human primates would be required before proceeding to clinical trials in seronegative infants.",

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author = "{de Waal}, Leon and Power, {Ultan F} and Selma Y{\"u}ksel and {van Amerongen}, Geert and Nguyen, {Thien N} and Niesters, {Hubert G M} and {de Swart}, {Rik L} and Osterhaus, {Albert D M E}",

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AU - de Waal, Leon

AU - Power, Ultan F

AU - Yüksel, Selma

AU - van Amerongen, Geert

AU - Nguyen, Thien N

AU - Niesters, Hubert G M

AU - de Swart, Rik L

AU - Osterhaus, Albert D M E

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AB - We have addressed the safety of alum-adsorbed BBG2Na, a recombinant respiratory syncytial virus (RSV) subunit vaccine, in infant macaques. Animals received two vaccinations, and were challenged 4 months later with RSV. In two of four BBG2Na-vaccinated animals, specific IL-13 producing T cells were detected. Upon challenge, low level pulmonary eosinophilia was observed in the same two animals. Although the levels of these responses were substantially lower than those observed in the FI-RSV controls, these data suggest that more extensive studies focusing on immunopathological safety of alum-adsorbed BBG2Na in non-human primates would be required before proceeding to clinical trials in seronegative infants.

KW - Animals

KW - Antibodies, Viral

KW - Immunoglobulin G

KW - Interleukin-13

KW - Macaca fascicularis

KW - Respiratory Syncytial Virus Infections

KW - Respiratory Syncytial Virus Vaccines

KW - Respiratory Syncytial Viruses

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Time Factors

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EP - 922

JO - Vaccine

JF - Vaccine

IS - 8

ER -

Evaluation of BBG2Na in infant macaques: specific immune responses after vaccination and RSV challenge

Abstract

Keywords

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