Evaluation of continuous beam rescanning versus pulsed beam in pencil beam scanned proton therapy for lung tumours

Cássia O Ribeiro; Jorvi Terpstra; Guillaume Janssens; Johannes A Langendijk; Stefan Both; Christina T Muijs; Robin Wijsman; Antje-Christin Knopf; Arturs Meijers

doi:10.1088/1361-6560/abc5c8

Evaluation of continuous beam rescanning versus pulsed beam in pencil beam scanned proton therapy for lung tumours

Cássia O Ribeiro^*
, Jorvi Terpstra
, Guillaume Janssens
, Johannes A Langendijk
, Stefan Both
, Christina T Muijs
, Robin Wijsman
, Antje-Christin Knopf
, Arturs Meijers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The treatment of moving targets with pencil beam scanned proton therapy (PBS-PT) may rely on rescanning strategies to smooth out motion induced dosimetric disturbances. PBS-PT machines, such as Proteus (R) Plus (PPlus) and Proteus (R) One (POne), deliver a continuous or a pulsed beam, respectively. In PPlus, scaled (or no) rescanning can be applied, while POne implies intrinsic 'rescanning' due to its pulsed delivery. We investigated the efficacy of these PBS-PT delivery types for the treatment of lung tumours. In general, clinically acceptable plans were achieved, and PPlus and POne showed similar effectiveness.

Original language	English
Article number	ARTN 23NT01
Number of pages	9
Journal	Physics in Medicine and Biology
Volume	65
Issue number	23
Early online date	2020
DOIs	https://doi.org/10.1088/1361-6560/abc5c8
Publication status	Published - 25-Nov-2020

Keywords

pencil beam scanned proton therapy
lung cancer
continuous beam
pulsed beam
rescanning
4D robustness evaluation
CLINICAL IMPLEMENTATION
ROBUSTNESS EVALUATION
RANGE UNCERTAINTIES
MOVING TARGETS
SPOT SIZE
MOTION
RADIOTHERAPY
SETUP
4D
OPTIMIZATION

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Evaluation of continuous beam rescanning versus pulsed beam in pencil beam scanned proton therapy for lung tumoursFinal publisher's version, 979 KBLicence: CC BY

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title = "Evaluation of continuous beam rescanning versus pulsed beam in pencil beam scanned proton therapy for lung tumours",

abstract = "The treatment of moving targets with pencil beam scanned proton therapy (PBS-PT) may rely on rescanning strategies to smooth out motion induced dosimetric disturbances. PBS-PT machines, such as Proteus (R) Plus (PPlus) and Proteus (R) One (POne), deliver a continuous or a pulsed beam, respectively. In PPlus, scaled (or no) rescanning can be applied, while POne implies intrinsic 'rescanning' due to its pulsed delivery. We investigated the efficacy of these PBS-PT delivery types for the treatment of lung tumours. In general, clinically acceptable plans were achieved, and PPlus and POne showed similar effectiveness.",

keywords = "pencil beam scanned proton therapy, lung cancer, continuous beam, pulsed beam, rescanning, 4D robustness evaluation, CLINICAL IMPLEMENTATION, ROBUSTNESS EVALUATION, RANGE UNCERTAINTIES, MOVING TARGETS, SPOT SIZE, MOTION, RADIOTHERAPY, SETUP, 4D, OPTIMIZATION",

author = "Ribeiro, \{C{\'a}ssia O\} and Jorvi Terpstra and Guillaume Janssens and Langendijk, \{Johannes A\} and Stefan Both and Muijs, \{Christina T\} and Robin Wijsman and Antje-Christin Knopf and Arturs Meijers",

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AU - Ribeiro, Cássia O

AU - Terpstra, Jorvi

AU - Janssens, Guillaume

AU - Langendijk, Johannes A

AU - Both, Stefan

AU - Muijs, Christina T

AU - Wijsman, Robin

AU - Knopf, Antje-Christin

AU - Meijers, Arturs

N1 - Creative Commons Attribution license.

PY - 2020/11/25

Y1 - 2020/11/25

N2 - The treatment of moving targets with pencil beam scanned proton therapy (PBS-PT) may rely on rescanning strategies to smooth out motion induced dosimetric disturbances. PBS-PT machines, such as Proteus (R) Plus (PPlus) and Proteus (R) One (POne), deliver a continuous or a pulsed beam, respectively. In PPlus, scaled (or no) rescanning can be applied, while POne implies intrinsic 'rescanning' due to its pulsed delivery. We investigated the efficacy of these PBS-PT delivery types for the treatment of lung tumours. In general, clinically acceptable plans were achieved, and PPlus and POne showed similar effectiveness.

AB - The treatment of moving targets with pencil beam scanned proton therapy (PBS-PT) may rely on rescanning strategies to smooth out motion induced dosimetric disturbances. PBS-PT machines, such as Proteus (R) Plus (PPlus) and Proteus (R) One (POne), deliver a continuous or a pulsed beam, respectively. In PPlus, scaled (or no) rescanning can be applied, while POne implies intrinsic 'rescanning' due to its pulsed delivery. We investigated the efficacy of these PBS-PT delivery types for the treatment of lung tumours. In general, clinically acceptable plans were achieved, and PPlus and POne showed similar effectiveness.

KW - pencil beam scanned proton therapy

KW - lung cancer

KW - continuous beam

KW - pulsed beam

KW - rescanning

KW - 4D robustness evaluation

KW - CLINICAL IMPLEMENTATION

KW - ROBUSTNESS EVALUATION

KW - RANGE UNCERTAINTIES

KW - MOVING TARGETS

KW - SPOT SIZE

KW - MOTION

KW - RADIOTHERAPY

KW - SETUP

KW - 4D

KW - OPTIMIZATION

U2 - 10.1088/1361-6560/abc5c8

DO - 10.1088/1361-6560/abc5c8

M3 - Article

C2 - 33120367

SN - 0031-9155

VL - 65

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

IS - 23

M1 - ARTN 23NT01

ER -

Evaluation of continuous beam rescanning versus pulsed beam in pencil beam scanned proton therapy for lung tumours

Abstract

Keywords

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