TY - JOUR
T1 - Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)
T2 - An update (2014-2018)
AU - Lefaucheur, Jean-Pascal
AU - Aleman, Andre
AU - Baeken, Chris
AU - Benninger, David H.
AU - Brunelin, Jerome
AU - Di Lazzaro, Vincenzo
AU - Filipovic, Sasa R.
AU - Grefkes, Christian
AU - Hasan, Alkomiet
AU - Hummel, Friedhelm C.
AU - Jaaskelainen, Satu K.
AU - Langguth, Berthold
AU - Leocani, Letizia
AU - Londero, Alain
AU - Nardone, Raffaele
AU - Nguyen, Jean-Paul
AU - Nyffeler, Thomas
AU - Oliveira-Maia, Albino J.
AU - Oliviero, Antonio
AU - Padberg, Frank
AU - Palm, Ulrich
AU - Paulus, Walter
AU - Poulet, Emmanuel
AU - Quartarone, Angelo
AU - Rachid, Fady
AU - Rektorova, Irena
AU - Rossi, Simone
AU - Sahlsten, Hanna
AU - Schecklmann, Martin
AU - Szekely, David
AU - Ziemann, Ulf
PY - 2020/5
Y1 - 2020/5
N2 - A group of European experts reappraised the guidelines on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) previously published in 2014 [Lefaucheur et al., Clin Neurophysiol 2014;125:2150–206]. These updated recommendations take into account all rTMS publications, including data prior to 2014, as well as currently reviewed literature until the end of 2018. Level A evidence (definite efficacy) was reached for: high-frequency (HF) rTMS of the primary motor cortex (M1) contralateral to the painful side for neuropathic pain; HF-rTMS of the left dorsolateral prefrontal cortex (DLPFC) using a figure-of-8 or a H1-coil for depression; low-frequency (LF) rTMS of contralesional M1 for hand motor recovery in the post-acute stage of stroke. Level B evidence (probable efficacy) was reached for: HF-rTMS of the left M1 or DLPFC for improving quality of life or pain, respectively, in fibromyalgia; HF-rTMS of bilateral M1 regions or the left DLPFC for improving motor impairment or depression, respectively, in Parkinson's disease; HF-rTMS of ipsilesional M1 for promoting motor recovery at the post-acute stage of stroke; intermittent theta burst stimulation targeted to the leg motor cortex for lower limb spasticity in multiple sclerosis; HF-rTMS of the right DLPFC in posttraumatic stress disorder; LF-rTMS of the right inferior frontal gyrus in chronic post-stroke non-fluent aphasia; LF-rTMS of the right DLPFC in depression; and bihemispheric stimulation of the DLPFC combining right-sided LF-rTMS (or continuous theta burst stimulation) and left-sided HF-rTMS (or intermittent theta burst stimulation) in depression. Level A/B evidence is not reached concerning efficacy of rTMS in any other condition. The current recommendations are based on the differences reached in therapeutic efficacy of real vs. sham rTMS protocols, replicated in a sufficient number of independent studies. This does not mean that the benefit produced by rTMS inevitably reaches a level of clinical relevance.
AB - A group of European experts reappraised the guidelines on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) previously published in 2014 [Lefaucheur et al., Clin Neurophysiol 2014;125:2150–206]. These updated recommendations take into account all rTMS publications, including data prior to 2014, as well as currently reviewed literature until the end of 2018. Level A evidence (definite efficacy) was reached for: high-frequency (HF) rTMS of the primary motor cortex (M1) contralateral to the painful side for neuropathic pain; HF-rTMS of the left dorsolateral prefrontal cortex (DLPFC) using a figure-of-8 or a H1-coil for depression; low-frequency (LF) rTMS of contralesional M1 for hand motor recovery in the post-acute stage of stroke. Level B evidence (probable efficacy) was reached for: HF-rTMS of the left M1 or DLPFC for improving quality of life or pain, respectively, in fibromyalgia; HF-rTMS of bilateral M1 regions or the left DLPFC for improving motor impairment or depression, respectively, in Parkinson's disease; HF-rTMS of ipsilesional M1 for promoting motor recovery at the post-acute stage of stroke; intermittent theta burst stimulation targeted to the leg motor cortex for lower limb spasticity in multiple sclerosis; HF-rTMS of the right DLPFC in posttraumatic stress disorder; LF-rTMS of the right inferior frontal gyrus in chronic post-stroke non-fluent aphasia; LF-rTMS of the right DLPFC in depression; and bihemispheric stimulation of the DLPFC combining right-sided LF-rTMS (or continuous theta burst stimulation) and left-sided HF-rTMS (or intermittent theta burst stimulation) in depression. Level A/B evidence is not reached concerning efficacy of rTMS in any other condition. The current recommendations are based on the differences reached in therapeutic efficacy of real vs. sham rTMS protocols, replicated in a sufficient number of independent studies. This does not mean that the benefit produced by rTMS inevitably reaches a level of clinical relevance.
KW - Cortex
KW - Indication
KW - Neurology
KW - Neuromodulation
KW - Noninvasive brain stimulation
KW - Psychiatry
KW - Treatment
KW - THETA-BURST STIMULATION
KW - DORSOLATERAL PREFRONTAL CORTEX
KW - OBSESSIVE-COMPULSIVE DISORDER
KW - NONINVASIVE BRAIN-STIMULATION
KW - SHAM-CONTROLLED-TRIAL
KW - HIGH-FREQUENCY RTMS
KW - MAJOR DEPRESSIVE DISORDER
KW - TREATMENT-RESISTANT DEPRESSION
KW - PREDOMINANT NEGATIVE SYMPTOMS
KW - AUDITORY VERBAL HALLUCINATIONS
U2 - 10.1016/j.clinph.2019.11.002
DO - 10.1016/j.clinph.2019.11.002
M3 - Review article
VL - 131
SP - 474
EP - 528
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 2
ER -