EVIDENCE-BASED REVIEW OF TREATMENT OPTIONS FOR PATIENTS WITH GLOTTIC CANCER

Dana M. Hartl*, Alfio Ferlito, Daniel F. Brasnu, Johannes A. Langendijk, Alessandra Rinaldo, Carl E. Silver, Gregory T. Wolf

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

87 Citations (Scopus)

Abstract

Evidence-based medicine integrates the best available data in decision making, with the goal of minimizing physicians' and patients' subjectivity. In 2006, the American Society of Clinical Oncology edited clinical practice guidelines for the use of larynx preservation strategies. The objective of this review was to evaluate the current levels of evidence for glottic squamous cell carcinoma. Current guidelines for early stage glottic cancer are based on low-level evidence. Conservation surgery (open or transoral) and radiation therapy are all valid options for T1 and selected T2 lesions. For advanced lesions, surgery and combined chemotherapy and radiation are options. High-level evidence favors combined chemotherapy and radiation therapy or altered fractionation radiation therapy as nonsurgical strategies for organ preservation, compared with radiation therapy alone. The optimal combination of chemotherapy, targeted therapy, and radiation therapy remains to be demonstrated, however, and for high-volume tumors, total laryngectomy may still be warranted. (C) 2011 Wiley Periodicals, Inc. Head Neck 33: 1638-1648, 2011

Original languageEnglish
Pages (from-to)1638-1648
Number of pages11
JournalHead and Neck: Journal of the Sciences and Specialties of the Head and Neck
Volume33
Issue number11
DOIs
Publication statusPublished - Nov-2011

Keywords

  • glottic cancer
  • surgery
  • transoral laser
  • radiotherapy
  • chemotherapy
  • SQUAMOUS-CELL CARCINOMA
  • SUPRACRICOID PARTIAL LARYNGECTOMY
  • VERTICAL PARTIAL LARYNGECTOMY
  • QUALITY-OF-LIFE
  • TRUE VOCAL CORD
  • CARBON-DIOXIDE LASER
  • ANTERIOR COMMISSURE INVOLVEMENT
  • RADIATION ONCOLOGY CENTERS
  • NEAR-TOTAL LARYNGECTOMY
  • LOCAL-CONTROL

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