Evidence for non-random distribution of Fc gamma receptor genotype combinations

WL van der Pol; MD Jansen; WJ Sluiter; B van de Sluis; FGJ Leppers-van de Straat; T Kobayashi; RGJ Westendorp; TWJ Huizinga; JGJ van de Winkel

doi:10.1007/s00251-003-0574-9

Evidence for non-random distribution of Fc gamma receptor genotype combinations

WL van der Pol^*, MD Jansen, WJ Sluiter, B van de Sluis, FGJ Leppers-van de Straat, T Kobayashi, RGJ Westendorp, TWJ Huizinga, JGJ van de Winkel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

55 Citations (Scopus)

Abstract

Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. Linked transmission of FcgammaR alleles was studied by determining the distribution of FcgammaRIIA-FcgammaRIIIA-FcgammaRIIIB genotype combinations in 514 Dutch Caucasian, and 149 Japanese blood donors. The structure of the FcgammaR locus was studied by radiation hybrid mapping of FcgammaRIA, FcgammaRIIA, FcgammaRIIB, FcgammaRIIIA, FcgammaRIIIB, and adjacent genes from the pentraxin family. In addition, crossing-over frequencies within the FcgammaR locus were determined in 63 Dutch Caucasian families, encompassing 183 individuals. FcgammaRII and FcgammaRIII subclasses were mapped in close proximity (0.47-3.14 cR). Accordingly, crossing-over frequencies within the FcgammaRII-III locus in Dutch families were low. Analysis of combined FcgammaR genotypes strongly suggested non-random distribution of FcgammaRIIA-FcgammaRIIIA-, and FcgammaRIIIA-FcgammaRIIIB genotypes in Dutch donors (P

Original language	English
Pages (from-to)	240-246
Number of pages	7
Journal	Immunogenetics
Volume	55
Issue number	4
DOIs	https://doi.org/10.1007/s00251-003-0574-9
Publication status	Published - Jul-2003

Keywords

Fc gamma receptors
human
polymorphism
SYSTEMIC-LUPUS-ERYTHEMATOSUS
SINGLE NUCLEOTIDE SUBSTITUTIONS
RIIA CD32
MENINGOCOCCAL DISEASE
ARTHUS REACTION
DEFICIENT MICE
IGG SUBCLASSES
RISK-FACTORS
POLYMORPHISM
GENE

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@article{f93bcb5755b744b1b3758f707d3301f6,

title = "Evidence for non-random distribution of Fc gamma receptor genotype combinations",

abstract = "Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. Linked transmission of FcgammaR alleles was studied by determining the distribution of FcgammaRIIA-FcgammaRIIIA-FcgammaRIIIB genotype combinations in 514 Dutch Caucasian, and 149 Japanese blood donors. The structure of the FcgammaR locus was studied by radiation hybrid mapping of FcgammaRIA, FcgammaRIIA, FcgammaRIIB, FcgammaRIIIA, FcgammaRIIIB, and adjacent genes from the pentraxin family. In addition, crossing-over frequencies within the FcgammaR locus were determined in 63 Dutch Caucasian families, encompassing 183 individuals. FcgammaRII and FcgammaRIII subclasses were mapped in close proximity (0.47-3.14 cR). Accordingly, crossing-over frequencies within the FcgammaRII-III locus in Dutch families were low. Analysis of combined FcgammaR genotypes strongly suggested non-random distribution of FcgammaRIIA-FcgammaRIIIA-, and FcgammaRIIIA-FcgammaRIIIB genotypes in Dutch donors (P",

keywords = "Fc gamma receptors, human, polymorphism, SYSTEMIC-LUPUS-ERYTHEMATOSUS, SINGLE NUCLEOTIDE SUBSTITUTIONS, RIIA CD32, MENINGOCOCCAL DISEASE, ARTHUS REACTION, DEFICIENT MICE, IGG SUBCLASSES, RISK-FACTORS, POLYMORPHISM, GENE",

author = "{van der Pol}, WL and MD Jansen and WJ Sluiter and {van de Sluis}, B and {Leppers-van de Straat}, FGJ and T Kobayashi and RGJ Westendorp and TWJ Huizinga and {van de Winkel}, JGJ",

year = "2003",

month = jul,

doi = "10.1007/s00251-003-0574-9",

language = "English",

volume = "55",

pages = "240--246",

journal = "Immunogenetics",

issn = "0093-7711",

publisher = "Springer",

number = "4",

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TY - JOUR

T1 - Evidence for non-random distribution of Fc gamma receptor genotype combinations

AU - van der Pol, WL

AU - Jansen, MD

AU - Sluiter, WJ

AU - van de Sluis, B

AU - Leppers-van de Straat, FGJ

AU - Kobayashi, T

AU - Westendorp, RGJ

AU - Huizinga, TWJ

AU - van de Winkel, JGJ

PY - 2003/7

Y1 - 2003/7

N2 - Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. Linked transmission of FcgammaR alleles was studied by determining the distribution of FcgammaRIIA-FcgammaRIIIA-FcgammaRIIIB genotype combinations in 514 Dutch Caucasian, and 149 Japanese blood donors. The structure of the FcgammaR locus was studied by radiation hybrid mapping of FcgammaRIA, FcgammaRIIA, FcgammaRIIB, FcgammaRIIIA, FcgammaRIIIB, and adjacent genes from the pentraxin family. In addition, crossing-over frequencies within the FcgammaR locus were determined in 63 Dutch Caucasian families, encompassing 183 individuals. FcgammaRII and FcgammaRIII subclasses were mapped in close proximity (0.47-3.14 cR). Accordingly, crossing-over frequencies within the FcgammaRII-III locus in Dutch families were low. Analysis of combined FcgammaR genotypes strongly suggested non-random distribution of FcgammaRIIA-FcgammaRIIIA-, and FcgammaRIIIA-FcgammaRIIIB genotypes in Dutch donors (P

AB - Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. Linked transmission of FcgammaR alleles was studied by determining the distribution of FcgammaRIIA-FcgammaRIIIA-FcgammaRIIIB genotype combinations in 514 Dutch Caucasian, and 149 Japanese blood donors. The structure of the FcgammaR locus was studied by radiation hybrid mapping of FcgammaRIA, FcgammaRIIA, FcgammaRIIB, FcgammaRIIIA, FcgammaRIIIB, and adjacent genes from the pentraxin family. In addition, crossing-over frequencies within the FcgammaR locus were determined in 63 Dutch Caucasian families, encompassing 183 individuals. FcgammaRII and FcgammaRIII subclasses were mapped in close proximity (0.47-3.14 cR). Accordingly, crossing-over frequencies within the FcgammaRII-III locus in Dutch families were low. Analysis of combined FcgammaR genotypes strongly suggested non-random distribution of FcgammaRIIA-FcgammaRIIIA-, and FcgammaRIIIA-FcgammaRIIIB genotypes in Dutch donors (P

KW - Fc gamma receptors

KW - human

KW - polymorphism

KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS

KW - SINGLE NUCLEOTIDE SUBSTITUTIONS

KW - RIIA CD32

KW - MENINGOCOCCAL DISEASE

KW - ARTHUS REACTION

KW - DEFICIENT MICE

KW - IGG SUBCLASSES

KW - RISK-FACTORS

KW - POLYMORPHISM

KW - GENE

U2 - 10.1007/s00251-003-0574-9

DO - 10.1007/s00251-003-0574-9

M3 - Article

SN - 0093-7711

VL - 55

SP - 240

EP - 246

JO - Immunogenetics

JF - Immunogenetics

IS - 4

ER -

Evidence for non-random distribution of Fc gamma receptor genotype combinations

Abstract

Keywords

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