Evolutionary dynamics of dengue virus populations within the mosquito vector

Louis Lambrechts*, Sebastian Lequime

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

To date, dengue virus evolution has mainly been addressed by studies conducted at the between-host level. Like other pathogens with high mutation rate and rapid replication, dengue viruses also evolve during the course of an infection. Over the last few years, the advent of deep-sequencing technologies has facilitated studies of dengue virus populations at the within-host level. Here, we review recent advances on the evolutionary dynamics of dengue virus populations within their mosquito vector. We discuss how identifying the evolutionary forces acting on dengue virus populations within the mosquito can shed light on the processes underlying vector-virus interactions and the evolution of epidemiologically relevant traits.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalCurrent opinion in virology
Volume21
DOIs
Publication statusPublished - Dec-2016
Externally publishedYes

Keywords

  • Animals
  • Biological Evolution
  • Dengue Virus/classification
  • Genetic Variation
  • Genetics, Population
  • Host-Pathogen Interactions
  • Mosquito Vectors/virology
  • Population Dynamics

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