Exercise Effects on Multiple Sclerosis Quality of Life and Clinical-Motor Symptoms

József Tollár, Ferenc Nagy, Béla E Tóth, Katalin Török, Kinga Szita, Bence Csutorás, Mariann Moizs, Tibor Hortobágyi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Introduction Different therapies can improve clinical and motor symptoms of multiple sclerosis (MS) similarly, but studies comparing the effects of different exercise therapies on clinical and motor outcomes are scant. We compared the effects of exergaming (EXE), balance (BAL), cycling (CYC), proprioceptive neuromuscular facilitation (PNF), and a standard care wait-listed control group (CON) on clinical and motor symptoms and quality of life (QoL) in people with MS (PwMS). Methods PwMS (n = 68, 90% female; age, 47.0 yr; Expanded Disability Status Scale score 5-6) were randomized into five groups. Before and after the interventions (five times a week for 5 wk), PwMS were tested for MS-related clinical and motor symptoms (Multiple Sclerosis Impact Scale-29 (MSIS-29), primary outcome), QoL (EuroQol Five Dimensions Questionnaire), symptoms of depression, gait and balance ability (Tinetti Assessment Tool), static and dynamic balance and fall risk (Berg Balance Scale), walking capacity (6-min walk test), and standing posturography on a force platform. Results EXE, BAL, and CYC improved the MSIS-29 scores similarly. EXE and CYC improved QoL and walking capacity similarly but more than BAL. Only EXE improved gait and balance scores (Tinetti Assessment Tool). EXE and BAL improved fall risk and standing balance similarly but more than CYC. PNF and CON revealed no changes. The EuroQol Five Dimensions Questionnaire moderated the exercise effects on the MSIS-29 scores only in EXE. Changes in QoL and changes in the MSIS-29 scores correlated (R2 = 0.73) only in EXE. Conclusion In conclusion, BAL and CYC but EXE in particular, but not PNF, can improve clinical and motor symptoms and QoL in PwMS (Expanded Disability Status Scale score 5 to 6), expanding the evidence-based exercise options to reduce mobility limitations in PwMS.

Original languageEnglish
Pages (from-to)1007-1014
Number of pages8
JournalMEDICINE AND SCIENCE IN SPORTS AND EXERCISE
Volume52
Issue number5
Early online date23-Dec-2019
DOIs
Publication statusPublished - May-2020

Keywords

  • EXERCISE SPECIFICITY
  • SENSORIMOTOR TRAINING
  • POSTURE
  • IMPACT-SCALE MSIS-29
  • VALIDITY
  • MOBILITY
  • BALANCE
  • PEOPLE
  • GAIT
  • RELIABILITY
  • FATIGUE
  • REHABILITATION
  • IMPROVEMENT

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