Experimental autologous substitute vascular graft for transplantation surgery

L Kobori*, G Dallos, ASH Gouw, T Nemeth, B Nemes, I Fehervari, Adam Tegzess, MJH Slooff, F Perner, KP De Jong

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)


Vascular complications in fiver transplantation are a major cause of graft failure and mortality. The aim of the study was to create autologous vascular graft without risk of rejection. Posterior rectus fascia sheath lined with peritoneum was used for iliac artery replacement in seven mongrel dogs. The patency was followed by palpation and Doppler ultrasound. The grafts were removed after one month. Five grafts remained patent. The Doppler showed good, relatively increased flow (median flow rate: 383 cm/sec) after one month in all of the cases. Slight increase in diameter was present in all cases. By microscopy the five patent grafts showed viable morphology, fibroblasts, smooth muscle cells and thin fibrin layer in the wall. The grafts were lined partially with a neoendothelial monolayer and a thin fibrin layer. In conclusion, this graft presents an acceptable patency rate and low thrombogenicity, and could be useful in transplantation. Further investigations are needed to study the effect of immunosuppression and rejection on long-term morphology and patency of the grafts.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalActa veterinaria hungarica
Issue number3
Publication statusPublished - 2000


  • rectus fascia sheath
  • experimental vascular graft
  • liver transplantation

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