Abstract
Complex material interfaces were designed and developed to explore cell-material interactions and elicit the relationship between biomaterial properties and biological performance to be used in the future as possible advanced tissue engineering and regenerative medicine approaches. Cells always integrate multiple cues from their microenvironment and we should include as many different parameters in our biomaterials as possible and study these for an accurate description of the cell state as a consequence of interacting with a material. In order to highly control cellular behavior, it is crucial to identify the optimal cell response by studying a detailed interaction between cells and materials over a broad range. The findings in this thesis are expected to act as a catalyst for other researchers to efficiently explore cell behavior from a more complex point of view. Our work is not just to obtain more knowledge on cell and material interactions, but to apply this knowledge for accelerating the development of high-performance biomaterials, which can become commercially available.
| Translated title of the contribution | Verkenning van de gecombineerde invloeden van de topografie, stijfheid en chemie van biomateriaaloppervlakken op het gedrag van cellen |
|---|---|
| Original language | English |
| Qualification | Doctor of Philosophy |
| Awarding Institution |
|
| Supervisors/Advisors |
|
| Award date | 11-Jul-2018 |
| Place of Publication | [Groningen] |
| Publisher | |
| Print ISBNs | 978-94-034-0780-7 |
| Electronic ISBNs | 978-94-034-0779-1 |
| Publication status | Published - 2018 |