TY - JOUR
T1 - Exploring Current Diagnosis and Management of Amiodarone-induced Thyrotoxicosis
AU - Oktaviono, Yudi Her
AU - Mustofa, Ali
AU - Saputra, Pandit Bagus Tri
AU - Widiarti, Wynne
AU - Faizah, Novia Nurul
AU - Alkaff, Firas Farisi
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/5/1
Y1 - 2025/5/1
N2 - Amiodarone, commonly used to treat various types of arrhythmias, can potentially lead to catastrophic adverse effects like amiodarone-induced thyrotoxicosis (AIT). This review offers insights into diagnosing and managing AIT, involving thyroid function tests, imaging techniques, and strategies to prevent cardiac deterioration and reduce mortality. The approach to managing AIT has shifted from focusing on thyrotoxicosis control to a broader strategy that includes preventing heart deterioration, hospitalizations, and reducing mortality. Healthcare professionals should consider the patient's need for amiodarone, side effects, coexisting conditions, and personal perspective. Routine thyroid function monitoring and collaboration across medical specialties are essential for comprehensive AIT management. Effective management of AIT is crucial to diminish mortality and morbidity. Pharmacological treatment can be initiated. Further intervention such as thyroidectomy is recommended, especially in cases where cardiac status is deteriorating and amiodarone continuation is necessary. In conclusion, early diagnosis and timely treatment through interdisciplinary collaboration according to specific individual case are crucial to reduce morbidity and mortality in AIT patients.
AB - Amiodarone, commonly used to treat various types of arrhythmias, can potentially lead to catastrophic adverse effects like amiodarone-induced thyrotoxicosis (AIT). This review offers insights into diagnosing and managing AIT, involving thyroid function tests, imaging techniques, and strategies to prevent cardiac deterioration and reduce mortality. The approach to managing AIT has shifted from focusing on thyrotoxicosis control to a broader strategy that includes preventing heart deterioration, hospitalizations, and reducing mortality. Healthcare professionals should consider the patient's need for amiodarone, side effects, coexisting conditions, and personal perspective. Routine thyroid function monitoring and collaboration across medical specialties are essential for comprehensive AIT management. Effective management of AIT is crucial to diminish mortality and morbidity. Pharmacological treatment can be initiated. Further intervention such as thyroidectomy is recommended, especially in cases where cardiac status is deteriorating and amiodarone continuation is necessary. In conclusion, early diagnosis and timely treatment through interdisciplinary collaboration according to specific individual case are crucial to reduce morbidity and mortality in AIT patients.
KW - amiodarone
KW - hyperthyroid
KW - management
KW - mortality
KW - side effect
KW - thyrotoxicosis
UR - https://www.scopus.com/pages/publications/85218244232
U2 - 10.1016/j.amjcard.2025.02.002
DO - 10.1016/j.amjcard.2025.02.002
M3 - Review article
C2 - 39924094
AN - SCOPUS:85218244232
SN - 0002-9149
VL - 242
SP - 75
EP - 81
JO - American Journal of Cardiology
JF - American Journal of Cardiology
ER -