Export and modification of (poly)peptides in the lantibiotic way

Gert Nikolaas Moll (Inventor), Cornelis Johannes Leenhouts (Inventor), Oscar Paul Kuipers (Inventor), Arnold Jacob Mathieu Driessen (Inventor)

Research output: Patent

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Abstract

The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine-containing peptides, wherein extracellularly thioether rings may be formed.
Original languageEnglish
Patent numberWO03099862
Priority date24/05/2002
Filing date26/05/2003
Publication statusPublished - 4-Dec-2003

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