Exposure to multiple heavy metals associate with aberrant immune homeostasis and inflammatory activation in preschool children

Yu Zhang, Xia Huo, Xueling Lu, Zhijun Zeng, Marijke M. Faas, Xijin Xu*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

Heavy metals generate adverse health effects by interfering with immune homeostasis and promoting inflammation in individuals. Our objective was to explore the induction of immune and inflammatory responses by multiple heavy metals in children living in the e-waste contaminated area. A total of 147 preschool children were recruited, including 73 children from Guiyu, a typical e-waste recycling area, and 74 from a reference group. Blood levels of heavy metals, including lead (Pb), cadmium (Cd), mercury (Hg) and arsenic (As), were detected using an inductively coupled plasma mass spectrometry (ICP-MS). Immune cell counts (neutrophils, monocytes, lymphocytes) were determined by an automatic blood cell analyzer, pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) and anti-inflammatory cytokines (IL-1RA, IL-4, IL-10, IL-13) were analyzed by a Luminex 200 multiplex immunoassay instrument. Multiple correspondences and linear regression analyses were applied to investigate the relationships between heavy metal exposure and relevant parameters. Results shows Guiyu children had higher levels of Pb, Cd, Hg, As, IL-1β and IL-6, but decreased lymphocyte, IL-1RA and IL-13. Neutrophil count was positively correlated with Pb, Cd and Hg exposure. Anti-inflammatory IL-1RA concentration was negatively related with Pb, Cd, Hg and As, while pro-inflammatory IL-1β and IL-6 were positively correlated with Pb. Guiyu children may have dysregulated immune response and high inflammation risk. Exposure to Pb, Cd, Hg and As could be harmful for immune response and inflammatory regulation. Our finding of decreased IL-RA production in children exposed to Pb, Cd, Hg, and As is novel and could be an opportunity for future research.

Original languageEnglish
Article number127257
Pages (from-to)127257
Number of pages11
JournalChemosphere
Volume257
DOIs
Publication statusPublished - Oct-2020
Event25th Topical Meeting of the International-Society-of-Electrochemistry (ISE) - Toledo, Spain
Duration: 12-May-201915-May-2019

Keywords

  • Heavy metal
  • Immune homeostasis
  • Inflammatory response
  • e-waste
  • Preschool children
  • HEALTH-RISK ASSESSMENT
  • WASTE RECYCLING TOWN
  • ELEVATED LEAD LEVELS
  • TRACE-ELEMENTS
  • AIR-POLLUTION
  • MOLECULAR-MECHANISMS
  • OXIDATIVE STRESS
  • DENDRITIC CELLS
  • SURFACE DUST
  • BLOOD LEAD

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