TY - JOUR
T1 - Expression Atlas update
T2 - gene and protein expression in multiple species
AU - Moreno, Pablo
AU - Fexova, Silvie
AU - George, Nancy
AU - Manning, Jonathan R
AU - Miao, Zhichiao
AU - Mohammed, Suhaib
AU - Muñoz-Pomer, Alfonso
AU - Fullgrabe, Anja
AU - Bi, Yalan
AU - Bush, Natassja
AU - Iqbal, Haider
AU - Kumbham, Upendra
AU - Solovyev, Andrey
AU - Zhao, Lingyun
AU - Prakash, Ananth
AU - García-Seisdedos, David
AU - Kundu, Deepti J
AU - Wang, Shengbo
AU - Walzer, Mathias
AU - Clarke, Laura
AU - Osumi-Sutherland, David
AU - Tello-Ruiz, Marcela Karey
AU - Kumari, Sunita
AU - Ware, Doreen
AU - Eliasova, Jana
AU - Arends, Mark J
AU - Nawijn, Martijn C
AU - Meyer, Kerstin
AU - Burdett, Tony
AU - Marioni, John
AU - Teichmann, Sarah
AU - Vizcaíno, Juan Antonio
AU - Brazma, Alvis
AU - Papatheodorou, Irene
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.
PY - 2022/1/7
Y1 - 2022/1/7
N2 - The EMBL-EBI Expression Atlas is an added value knowledge base that enables researchers to answer the question of where (tissue, organism part, developmental stage, cell type) and under which conditions (disease, treatment, gender, etc) a gene or protein of interest is expressed. Expression Atlas brings together data from >4500 expression studies from >65 different species, across different conditions and tissues. It makes these data freely available in an easy to visualise form, after expert curation to accurately represent the intended experimental design, re-analysed via standardised pipelines that rely on open-source community developed tools. Each study's metadata are annotated using ontologies. The data are re-analyzed with the aim of reproducing the original conclusions of the underlying experiments. Expression Atlas is currently divided into Bulk Expression Atlas and Single Cell Expression Atlas. Expression Atlas contains data from differential studies (microarray and bulk RNA-Seq) and baseline studies (bulk RNA-Seq and proteomics), whereas Single Cell Expression Atlas is currently dedicated to Single Cell RNA-Sequencing (scRNA-Seq) studies. The resource has been in continuous development since 2009 and it is available at https://www.ebi.ac.uk/gxa.
AB - The EMBL-EBI Expression Atlas is an added value knowledge base that enables researchers to answer the question of where (tissue, organism part, developmental stage, cell type) and under which conditions (disease, treatment, gender, etc) a gene or protein of interest is expressed. Expression Atlas brings together data from >4500 expression studies from >65 different species, across different conditions and tissues. It makes these data freely available in an easy to visualise form, after expert curation to accurately represent the intended experimental design, re-analysed via standardised pipelines that rely on open-source community developed tools. Each study's metadata are annotated using ontologies. The data are re-analyzed with the aim of reproducing the original conclusions of the underlying experiments. Expression Atlas is currently divided into Bulk Expression Atlas and Single Cell Expression Atlas. Expression Atlas contains data from differential studies (microarray and bulk RNA-Seq) and baseline studies (bulk RNA-Seq and proteomics), whereas Single Cell Expression Atlas is currently dedicated to Single Cell RNA-Sequencing (scRNA-Seq) studies. The resource has been in continuous development since 2009 and it is available at https://www.ebi.ac.uk/gxa.
U2 - 10.1093/nar/gkab1030
DO - 10.1093/nar/gkab1030
M3 - Article
C2 - 34850121
SN - 0305-1048
VL - 50
SP - 129
EP - 140
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
M1 - gkab1030
ER -