Expression of the stem cell marker ALDH1 in BRCA1 related breast cancer

Marise R. Heerma van Voss, Petra van der Groep, Joost Bart, Elsken van der Wall, Paul J. van Diest*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)
174 Downloads (Pure)

Abstract

Introduction The BRCA1 protein makes mammary stem cells differentiate into mature luminal and myoepithelial cells. If a BRCA1 mutation results in a differentiation block, an enlarged stem cell component might be present in the benign tissue of BRCA1 mutation carriers, and these mammary stem cells could be the origin of BRCA1 related breast cancer. Since ALDH1 is a marker of both mammary stem cells and breast cancer stem cells, we compared ALDH1 expression in malignant tissue of BRCA1 mutation carriers to non-carriers.

Methods Forty-one BRCA1 related breast cancers and 41 age-matched sporadic breast cancers were immunohistochemically stained for ALDH1. Expression in epithelium and stroma was scored and compared.

Results Epithelial (P=0.001) and peritumoral (P=0.001) ALDH1 expression was significantly higher in invasive BRCA1 related carcinomas compared to sporadic carcinomas. Intratumoral stromal ALDH1 expression was similarly high in both groups. ALDH1 tumor cell expression was an independent predictor of BRCA1 mutation status.

Conclusion BRCA1 related breast cancers showed significantly more frequent epithelial ALDH1 expression, indicating that these hereditary tumors have an enlarged cancer stem cell component. Besides, (peritumoral) stromal ALDH1 expression was also more frequent in BRCA1 mutation carriers. ALDH1 may therefore be a diagnostic marker and a therapeutic target of BRCA1 related breast cancer.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalCellular oncology
Volume34
Issue number1
DOIs
Publication statusPublished - Feb-2011

Keywords

  • Breast cancer
  • BRCA1
  • ALDH1
  • Stem cells
  • Hereditary breast cancer
  • MAMMARY EPITHELIAL-CELLS
  • ALDEHYDE DEHYDROGENASE
  • MUTATION CARRIERS
  • IN-VITRO
  • DIFFERENTIATION
  • CARCINOMA
  • POPULATION
  • PHENOTYPE
  • SUBTYPES

Cite this