Extensive introgression in a malaria vector species complex revealed by phylogenomics

M. C. Fontaine; J. B. Pease; A. Steele; R. M. Waterhouse; D. E. Neafsey; I. V. Sharakhov; X. Jiang; A. B. Hall; F. Catteruccia; E. Kakani; S. N. Mitchell; Y.-c. Wu; H. A. Smith; R. R. Love; M. K. Lawniczak; M. A. Slotman; S. J. Emrich; M. W. Hahn; N. J. Besansky

doi:10.1126/science.1258524

Extensive introgression in a malaria vector species complex revealed by phylogenomics

M. C. Fontaine, J. B. Pease, A. Steele, R. M. Waterhouse, D. E. Neafsey, I. V. Sharakhov, X. Jiang, A. B. Hall, F. Catteruccia, E. Kakani, S. N. Mitchell, Y.-c. Wu, H. A. Smith, R. R. Love, M. K. Lawniczak, M. A. Slotman, S. J. Emrich, M. W. Hahn, N. J. Besansky

Research output: Contribution to journal › Article › Academic › peer-review

398 Citations (Scopus)

Abstract

Introgressive hybridization is now recognized as a widespread phenomenon, but its role in evolution remains contested. Here we use newly available reference genome assemblies to investigate phylogenetic relationships and introgression in a medically important group of Afrotropical mosquito sibling species. We have identified the correct species branching order to resolve a contentious phylogeny and show that lineages leading to the principal vectors of human malaria were among the first to split. Pervasive autosomal introgression between these malaria vectors means that only a small fraction of the genome, mainly on the X chromosome, has not crossed species boundaries. Our results suggest that traits enhancing vectorial capacity may be gained through interspecific gene flow, including between nonsister species.

Original language	English
Article number	125824
Number of pages	7
Journal	Science
Volume	347
Issue number	6217
DOIs	https://doi.org/10.1126/science.1258524
Publication status	Published - 2-Jan-2015
Externally published	Yes

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Data from: Extensive introgression in a malaria vector species complex revealed by phylogenomics
Fontaine, M. (Contributor), Pease, J. B. (Contributor), Steele, A. (Contributor), Waterhouse, R. M. (Contributor), Neafsey, D. E. (Contributor), Sharakhov, I. V. (Contributor), Jiang, X. (Contributor), Hall, A. B. (Contributor), Catteruccia, F. (Contributor), Kakani, E. (Contributor), Mitchell, S. N. (Contributor), Wu, Y.-C. (Contributor), Smith, H. A. (Contributor), Rebecca Love (Contributor), Lawniczak, M. K. (Contributor), Slotman, M. A. (Contributor), Emrich, S. J. (Contributor), Hahn, M. W. (Contributor) & Besansky, N. J. (Contributor), University of Groningen, 3-Oct-2015
DOI: 10.5061/dryad.f4114, https://zenodo.org/record/4977873
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Nominee of the Omenn Prize 2014
Fontaine, M. (Recipient), 2014
Prize: Other distinction › Academic

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Fontaine, M. C., Pease, J. B., Steele, A., Waterhouse, R. M., Neafsey, D. E., Sharakhov, I. V., Jiang, X., Hall, A. B., Catteruccia, F., Kakani, E., Mitchell, S. N., Wu, Y., Smith, H. A., Love, R. R., Lawniczak, M. K., Slotman, M. A., Emrich, S. J., Hahn, M. W., & Besansky, N. J. (2015). Extensive introgression in a malaria vector species complex revealed by phylogenomics. Science, 347(6217), Article 125824. https://doi.org/10.1126/science.1258524

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title = "Extensive introgression in a malaria vector species complex revealed by phylogenomics",

abstract = "Introgressive hybridization is now recognized as a widespread phenomenon, but its role in evolution remains contested. Here we use newly available reference genome assemblies to investigate phylogenetic relationships and introgression in a medically important group of Afrotropical mosquito sibling species. We have identified the correct species branching order to resolve a contentious phylogeny and show that lineages leading to the principal vectors of human malaria were among the first to split. Pervasive autosomal introgression between these malaria vectors means that only a small fraction of the genome, mainly on the X chromosome, has not crossed species boundaries. Our results suggest that traits enhancing vectorial capacity may be gained through interspecific gene flow, including between nonsister species.",

author = "Fontaine, {M. C.} and Pease, {J. B.} and A. Steele and Waterhouse, {R. M.} and Neafsey, {D. E.} and Sharakhov, {I. V.} and X. Jiang and Hall, {A. B.} and F. Catteruccia and E. Kakani and Mitchell, {S. N.} and Y.-c. Wu and Smith, {H. A.} and Love, {R. R.} and Lawniczak, {M. K.} and Slotman, {M. A.} and Emrich, {S. J.} and Hahn, {M. W.} and Besansky, {N. J.}",

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doi = "10.1126/science.1258524",

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Fontaine, MC, Pease, JB, Steele, A, Waterhouse, RM, Neafsey, DE, Sharakhov, IV, Jiang, X, Hall, AB, Catteruccia, F, Kakani, E, Mitchell, SN, Wu, Y, Smith, HA, Love, RR, Lawniczak, MK, Slotman, MA, Emrich, SJ, Hahn, MW & Besansky, NJ 2015, 'Extensive introgression in a malaria vector species complex revealed by phylogenomics', Science, vol. 347, no. 6217, 125824. https://doi.org/10.1126/science.1258524

TY - JOUR

T1 - Extensive introgression in a malaria vector species complex revealed by phylogenomics

AU - Fontaine, M. C.

AU - Pease, J. B.

AU - Steele, A.

AU - Waterhouse, R. M.

AU - Neafsey, D. E.

AU - Sharakhov, I. V.

AU - Jiang, X.

AU - Hall, A. B.

AU - Catteruccia, F.

AU - Kakani, E.

AU - Mitchell, S. N.

AU - Wu, Y.-c.

AU - Smith, H. A.

AU - Love, R. R.

AU - Lawniczak, M. K.

AU - Slotman, M. A.

AU - Emrich, S. J.

AU - Hahn, M. W.

AU - Besansky, N. J.

PY - 2015/1/2

Y1 - 2015/1/2

N2 - Introgressive hybridization is now recognized as a widespread phenomenon, but its role in evolution remains contested. Here we use newly available reference genome assemblies to investigate phylogenetic relationships and introgression in a medically important group of Afrotropical mosquito sibling species. We have identified the correct species branching order to resolve a contentious phylogeny and show that lineages leading to the principal vectors of human malaria were among the first to split. Pervasive autosomal introgression between these malaria vectors means that only a small fraction of the genome, mainly on the X chromosome, has not crossed species boundaries. Our results suggest that traits enhancing vectorial capacity may be gained through interspecific gene flow, including between nonsister species.

AB - Introgressive hybridization is now recognized as a widespread phenomenon, but its role in evolution remains contested. Here we use newly available reference genome assemblies to investigate phylogenetic relationships and introgression in a medically important group of Afrotropical mosquito sibling species. We have identified the correct species branching order to resolve a contentious phylogeny and show that lineages leading to the principal vectors of human malaria were among the first to split. Pervasive autosomal introgression between these malaria vectors means that only a small fraction of the genome, mainly on the X chromosome, has not crossed species boundaries. Our results suggest that traits enhancing vectorial capacity may be gained through interspecific gene flow, including between nonsister species.

U2 - 10.1126/science.1258524

DO - 10.1126/science.1258524

M3 - Article

SN - 0036-8075

VL - 347

JO - Science

JF - Science

IS - 6217

M1 - 125824

ER -

Extensive introgression in a malaria vector species complex revealed by phylogenomics

Abstract

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Data from: Extensive introgression in a malaria vector species complex revealed by phylogenomics

Prizes

Nominee of the Omenn Prize 2014

Cite this