Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets

L Alberto Llacua, Marijke M Faas, Paul de Vos

Research output: Contribution to journalReview articleAcademicpeer-review

65 Citations (Scopus)
113 Downloads (Pure)

Abstract

Extracellular matrix (ECM) molecules are responsible for structural and biochemical support, as well as for regulation of molecular signalling and tissue repair in many organ structures, including the pancreas. In pancreatic islets, collagen type IV and VI, and laminins are the most abundant molecules, but other ECM molecules are also present. The ECM interacts with specific combinations of integrin α/β heterodimers on islet cells and guides many cellular processes. More specifically, some ECM molecules are involved in beta cell survival, function and insulin production, while others can fine tune the susceptibility of islet cells to cytokines. Further, some ECM induce release of growth factors to facilitate tissue repair. During enzymatic isolation of islets for transplantation, the ECM is damaged, impacting islet function. However, restoration of the ECM in human islets (for example by adding ECM to the interior of immunoprotective capsules) has been shown to enhance islet function. Here, we provide current insight into the role of ECM molecules in islet function and discuss the clinical potential of ECM manipulation to enhance pancreatic islet function and survival.

Original languageEnglish
Pages (from-to)1261-1272
Number of pages12
JournalDiabetologia
Volume61
Issue number6
Early online date6-Jan-2018
DOIs
Publication statusPublished - Jun-2018

Keywords

  • Collagen
  • Cytokines
  • Extracellular matrix
  • Graft
  • Islet
  • Laminin
  • Review
  • BETA-CELL SURVIVAL
  • NF-KAPPA-B
  • INSULIN-SECRETION
  • BASEMENT-MEMBRANE
  • HEPARAN-SULFATE
  • GROWTH-FACTORS
  • IN-VITRO
  • SUBCUTANEOUS SCAFFOLD
  • ENCAPSULATED ISLETS
  • EXOCRINE INTERFACE

Cite this