Extracellular matrix molecules applied to promote functional survival of microencapsulated pancreatic islets

Luis Alberto Llacua Carrasco

    Research output: ThesisThesis fully internal (DIV)

    332 Downloads (Pure)

    Abstract

    Diabetes is a chronic disease, which affects worldwide population. Although, this disease is well known for its devastating effects on the kidneys and vascular system, diabetic individuals can develop cardiac dysfunction, termed diabetic cardiomyopathy. While much effort has gone into understanding the effects of elevated glucose or altered insulin sensitivity on cellular components, significant changes in the islet-cell extracellular matrix
    (ECM) have also been observed to impact on the pancreatic islet metabolism and insulin release. In the present thesis, the experiments have been proposed to contribute for a better understanding of the impact of ECM(s) molecules in transplantation systems with islets. Using alginate-based capsule model in pancreatic islets, we have determined the ECM molecules with beneficial impact on islet-cell biology by in-vitro and in-vivo
    experiments for transplantation purposes. The use a bioluminescent mouse model to conduct in-vivo imaging to track the islet-graft survival have evidenced the role of ECM molecules plays in the islet survival. Finally, this study improved the development and application of immunoisolated islet for treatment of diabetes.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • de Vos, Paul, Supervisor
    • Faas, Marijke, Co-supervisor
    Award date7-Nov-2018
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-1095-1
    Electronic ISBNs978-94-034-1094-4
    Publication statusPublished - 2018

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