Extrapolating Survival Data Using Historical Trial-Based a Priori Distributions

Fanni Soikkeli*, Mahmoud Hashim, Mario Ouwens, Maarten Postma, Bart Heeg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
125 Downloads (Pure)


Objectives: To show how clinical trial data can be extrapolated using historical trial data-based a priori distributions.

Methods: Extrapolations based on 30-month pivotal multiplemyeloma trial data were compared with 75-month data from the same trial. The 30-month data represent a typical decision-making scenario where early results from a clinical trial are extrapolated. Mature historical trial data with the same comparator as in the pivotal trial were incorporated in 2 stages. First, the parametric distribution selection was based on the historical trial data. Second, the shape parameter estimate of the historical trial was used to define an informative a priori distribution for the shape of the 30-month pivotal trial data. The method was compared with standard approaches, fitting parametric distributions to the 30-month data with noninformative prior. The predicted survival of each method was compared with the observed survival (DAUC) in the 75-month trial data.

Results: The Weibull had the best fit to the historical trial and the log-normal to the 30-month pivotal trial data. The DAUC of the Weibull with informative priors was considerably smaller compared with the standard Weibull. Also, the predicted median survival based on the Weibull with informative priors was more accurate (melphalan and prednisone [MP] 40 months, and bortezomib [V] combined with MP [VMP] 62 months) than based on the standard Weibull (MP 45 months and VMP 72 months) when compared with the observed median (MP 41.3 months and VMP 56.4 months).

Conclusions: Extrapolation of clinical trial data is improved by using historical trial data-based informative a priori distributions.

Original languageEnglish
Pages (from-to)1012-1017
Number of pages6
JournalValue in Health
Issue number9
Publication statusPublished - Sep-2019


  • Bayesian statistics
  • multiple myeloma
  • oncology
  • overall survival
  • survival analysis

Cite this