F-18-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

H Hop; S A de Boer; M Reijrink; P W Kamphuisen; M H de Borst; R A Pol; C J Zeebregts; J L Hillebrands; R H J A Slart; H H Boersma; J Doorduin; D J Mulder

doi:10.1007/s12350-018-1325-5

F-18-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

H Hop, S A de Boer, M Reijrink, P W Kamphuisen, M H de Borst, R A Pol, C J Zeebregts, J L Hillebrands, R H J A Slart, H H Boersma, J Doorduin, D J Mulder

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Abstract

BACKGROUND: 18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18F-NaF uptake with calcification visualized on microcomputed tomography (microCT).

METHODS: Carotid plaques from stroke patients undergoing surgery were incubated in 18F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.

RESULTS: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18F-NaF PET VOI showed calcification on CT.

CONCLUSIONS: 18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.

Original language	English
Pages (from-to)	1064-1075
Number of pages	12
Journal	Journal of Nuclear Cardiology
Volume	26
Issue number	4
Early online date	25-Jun-2018
DOIs	https://doi.org/10.1007/s12350-018-1325-5
Publication status	Published - Aug-2019

Keywords

F-18-sodium fluoride (F-18-NaF)
Calcification
PET/CT imaging
Vulnerable atherosclerotic plaque
Carotid artery stenosis
ATHEROSCLEROTIC PLAQUE
VASCULAR CALCIFICATION
ENDARTERECTOMY
MARKER
PET/CT
FEASIBILITY
PROGRESSION
DENSITY
CALCIUM
IMPACT

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Frans J Th Wackers Award for Best Clinical Paper
Hop, H. (Recipient), Boer, de, S. (Recipient), Reijrink, M. (Recipient), Kamphuisen, P. W. (Recipient), Borst, de, M. (Recipient), Pol, R. (Recipient), Zeebregts, C. (Recipient), Hillebrands, J. L. (Recipient), Slart, R. (Recipient), Boersma, H. (Recipient), Doorduin, J. (Recipient) & Mulder, U. (Recipient), 2020
Prize › Academic

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Hop, H., de Boer, S. A., Reijrink, M., Kamphuisen, P. W., de Borst, M. H., Pol, R. A., Zeebregts, C. J., Hillebrands, J. L., Slart, R. H. J. A., Boersma, H. H., Doorduin, J., & Mulder, D. J. (2019). F-18-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques. Journal of Nuclear Cardiology, 26(4), 1064-1075. https://doi.org/10.1007/s12350-018-1325-5

@article{a82b53cadb9e4d3cbff4146ae61fea28,

title = "F-18-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques",

abstract = "BACKGROUND: 18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18F-NaF uptake with calcification visualized on microcomputed tomography (microCT).METHODS: Carotid plaques from stroke patients undergoing surgery were incubated in 18F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.RESULTS: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18F-NaF PET VOI showed calcification on CT.CONCLUSIONS: 18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.",

keywords = "F-18-sodium fluoride (F-18-NaF), Calcification, PET/CT imaging, Vulnerable atherosclerotic plaque, Carotid artery stenosis, ATHEROSCLEROTIC PLAQUE, VASCULAR CALCIFICATION, ENDARTERECTOMY, MARKER, PET/CT, FEASIBILITY, PROGRESSION, DENSITY, CALCIUM, IMPACT",

author = "H Hop and {de Boer}, {S A} and M Reijrink and Kamphuisen, {P W} and {de Borst}, {M H} and Pol, {R A} and Zeebregts, {C J} and Hillebrands, {J L} and Slart, {R H J A} and Boersma, {H H} and J Doorduin and Mulder, {D J}",

year = "2019",

month = aug,

doi = "10.1007/s12350-018-1325-5",

language = "English",

volume = "26",

pages = "1064--1075",

journal = "Journal of Nuclear Cardiology",

issn = "1071-3581",

publisher = "Springer",

number = "4",

}

Hop, H, de Boer, SA, Reijrink, M, Kamphuisen, PW, de Borst, MH , Pol, RA , Zeebregts, CJ , Hillebrands, JL , Slart, RHJA , Boersma, HH , Doorduin, J & Mulder, DJ 2019, 'F-18-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques', Journal of Nuclear Cardiology, vol. 26, no. 4, pp. 1064-1075. https://doi.org/10.1007/s12350-018-1325-5

TY - JOUR

T1 - F-18-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

AU - Hop, H

AU - de Boer, S A

AU - Reijrink, M

AU - Kamphuisen, P W

AU - de Borst, M H

AU - Pol, R A

AU - Zeebregts, C J

AU - Hillebrands, J L

AU - Slart, R H J A

AU - Boersma, H H

AU - Doorduin, J

AU - Mulder, D J

PY - 2019/8

Y1 - 2019/8

N2 - BACKGROUND: 18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18F-NaF uptake with calcification visualized on microcomputed tomography (microCT).METHODS: Carotid plaques from stroke patients undergoing surgery were incubated in 18F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.RESULTS: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18F-NaF PET VOI showed calcification on CT.CONCLUSIONS: 18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.

AB - BACKGROUND: 18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18F-NaF uptake with calcification visualized on microcomputed tomography (microCT).METHODS: Carotid plaques from stroke patients undergoing surgery were incubated in 18F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.RESULTS: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18F-NaF PET VOI showed calcification on CT.CONCLUSIONS: 18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.

KW - F-18-sodium fluoride (F-18-NaF)

KW - Calcification

KW - PET/CT imaging

KW - Vulnerable atherosclerotic plaque

KW - Carotid artery stenosis

KW - ATHEROSCLEROTIC PLAQUE

KW - VASCULAR CALCIFICATION

KW - ENDARTERECTOMY

KW - MARKER

KW - PET/CT

KW - FEASIBILITY

KW - PROGRESSION

KW - DENSITY

KW - CALCIUM

KW - IMPACT

U2 - 10.1007/s12350-018-1325-5

DO - 10.1007/s12350-018-1325-5

M3 - Article

C2 - 29943142

SN - 1071-3581

VL - 26

SP - 1064

EP - 1075

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

IS - 4

ER -

F-18-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

Abstract

Keywords

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Prizes

Frans J Th Wackers Award for Best Clinical Paper

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