Factors that influence disease-specific quality of life or health status in patients with COPD: a systematic review and meta-analysis of Pearson correlations

Ioanna Tsiligianni*, Janwillem Kocks, Nikolaos Tzanakis, Nikolaos Siafakas, Thys van der Molen

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

146 Citations (Scopus)

Abstract

Background: A major goal in the management of chronic obstructive pulmonary disease (COPD) is to ensure that the burden of the disease for patients with COPD is limited and that patients will have the best possible quality of life.

Aims: To explore all the possible factors that could influence disease-specific quality of life and health status in patients with COPD.

Methods: A systematic review of the literature and a meta-analysis were performed to explore the factors that could have a positive or negative effect on quality of life and/or health status in patients with COPD.

Results: Quality of life and health status are determined by certain factors included gender, disease severity indices, lung function parameters, body mass index, smoking, symptoms, co-morbidity, depression, anxiety, and exacerbations. Factors such as dyspnoea, depression, anxiety and exercise tolerance were found to be more correlated with health status than the widely used spirometric values. Forced expiratory volume in one second had a weak to modest Pearson weighted correlation coefficient which ranged from -0.110 to -0.510 depending on the questionnaire used.

Conclusions: The broad range of determining factors suggests that, in order to reach the management goals, health status should be measured in addition to lung function in patients with COPD. (C) 2011 Primary Care Respiratory Society UK. All rights reserved. I Tsiligianni, et al. Prim Care Respir J 2011; 20(3): 257-268 http://dx.doi.org/10.4104/pcrj.2011.00029

Original languageEnglish
Pages (from-to)257-268
Number of pages12
JournalPrimary Care Respiratory Journal
Volume20
Issue number3
DOIs
Publication statusPublished - Sep-2011

Keywords

  • chronic obstructive pulmonary disease
  • health status
  • quality of life
  • factor correlations
  • questionnaire
  • systematic review
  • OBSTRUCTIVE PULMONARY-DISEASE
  • GEORGES RESPIRATORY QUESTIONNAIRE
  • GENDER-ASSOCIATED DIFFERENCES
  • NONSPECIFIC LUNG-DISEASE
  • SICKNESS IMPACT PROFILE
  • HOME NEBULIZED THERAPY
  • AIR-FLOW OBSTRUCTION
  • BODY-MASS INDEX
  • PRIMARY-CARE
  • DEPRESSIVE SYMPTOMS

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