FADD Expression as a Prognosticator in Early-Stage Glottic Squamous Cell Carcinoma of the Larynx Treated Primarily With Radiotherapy

Michiel L. Schrijvers, Wouter J. Pattje, Lorian Slagter-Menkema, Mirjam F. Mastik, Johan H. Gibcus, Johannes A. Langendijk, Jacqueline E. van der Wal, Bernard F. A. M. van der Laan, E. Schuuring*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Abstract

Purpose: We recently reported on the identification of the Fas-associated death domain (FADD) as a possible driver of the chromosome 11q13 amplicon and the association between increased FADD expression and disease-specific survival in advanced-stage laryngeal carcinoma. The aim of this study was to examine whether expression of FADD and its Ser194-phosphorylated isoform (pFADD) predicts local control in patients with early-stage glottic carcinoma primarily treated with radiotherapy only.

Methods and Materials: Immunohistochemical staining for FADD and pFADD was performed on pretreatment biopsy specimens of 92 patients with T1-T2 glottic squamous cell carcinoma primarily treated with radiotherapy between 1996 and 2005. Cox regression analysis was used to correlate expression levels with local control.

Results: High levels of pFADD were associated with significantly better local control (hazard ratio, 2.40; 95% confidence interval, 1.04-5.55; p = 0.040). FADD overexpression showed a trend toward better local control (hazard ratio, 3.656; 95% confidence interval, 0.853-15.663; p = 0.081). Multivariate Cox regression analysis showed that high pFADD expression was the best predictor of local control after radiotherapy.

Conclusions: This study showed that expression of phosphorylated FADD is a new prognostic biomarker for better local control after radiotherapy in patients with early-stage glottic carcinomas. (C) 2012 Elsevier Inc.

Original languageEnglish
Pages (from-to)1220-1226
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume83
Issue number4
DOIs
Publication statusPublished - 15-Jul-2012

Keywords

  • FADD
  • Larynx
  • Prognostic marker
  • Radiotherapy
  • Squamous cell carcinoma
  • DOMAIN-CONTAINING PROTEIN
  • CYCLIN D1 OVEREXPRESSION
  • DEATH DOMAIN
  • CHROMOSOMAL-ABNORMALITIES
  • FAS
  • PHOSPHORYLATION
  • CANCER
  • SENSITIVITY
  • PROGRESSION
  • RADIATION

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