Failure to detect 6-hydroxydopamine in rat striatum after the dopamine releasing drugs dexamphetamine, methylamphetamine and MPTP

H  Rollema; JB de Vries; BHC Westerink; FMS van Putten; AS HORN

doi:10.1016/0014-2999(86)90011-7

Failure to detect 6-hydroxydopamine in rat striatum after the dopamine releasing drugs dexamphetamine, methylamphetamine and MPTP

H Rollema^*, JB de Vries, BHC Westerink , FMS van Putten, AS HORN

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

Large doses of dexamphetamine, methylamphetamine and MPTP failed to induce the formation of 6-hydroxydopamine (6-OHDA) in rat striatum. The potent dopamine (DA) releasing actions of these drugs and of the MPTP metabolite MPP+ were shown by intracerebral dialysis of DA in conscious rats but 6-OHDA was not detectible in the perfusates. Neurotoxic effects of these DA releasing drugs are therefore probably not due, as previously suggested, to 6-OHDA formation and its subsequent uptake into nerve terminals.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	European Journal of Pharmacology
Volume	132
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(86)90011-7
Publication status	Published - 2-Dec-1986

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title = "Failure to detect 6-hydroxydopamine in rat striatum after the dopamine releasing drugs dexamphetamine, methylamphetamine and MPTP",

abstract = "Large doses of dexamphetamine, methylamphetamine and MPTP failed to induce the formation of 6-hydroxydopamine (6-OHDA) in rat striatum. The potent dopamine (DA) releasing actions of these drugs and of the MPTP metabolite MPP+ were shown by intracerebral dialysis of DA in conscious rats but 6-OHDA was not detectible in the perfusates. Neurotoxic effects of these DA releasing drugs are therefore probably not due, as previously suggested, to 6-OHDA formation and its subsequent uptake into nerve terminals.",

author = "H Rollema and {de Vries}, JB and BHC Westerink and {van Putten}, FMS and AS HORN",

year = "1986",

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TY - JOUR

T1 - Failure to detect 6-hydroxydopamine in rat striatum after the dopamine releasing drugs dexamphetamine, methylamphetamine and MPTP

AU - Rollema, H

AU - de Vries, JB

AU - Westerink , BHC

AU - van Putten, FMS

AU - HORN, AS

PY - 1986/12/2

Y1 - 1986/12/2

N2 - Large doses of dexamphetamine, methylamphetamine and MPTP failed to induce the formation of 6-hydroxydopamine (6-OHDA) in rat striatum. The potent dopamine (DA) releasing actions of these drugs and of the MPTP metabolite MPP+ were shown by intracerebral dialysis of DA in conscious rats but 6-OHDA was not detectible in the perfusates. Neurotoxic effects of these DA releasing drugs are therefore probably not due, as previously suggested, to 6-OHDA formation and its subsequent uptake into nerve terminals.

AB - Large doses of dexamphetamine, methylamphetamine and MPTP failed to induce the formation of 6-hydroxydopamine (6-OHDA) in rat striatum. The potent dopamine (DA) releasing actions of these drugs and of the MPTP metabolite MPP+ were shown by intracerebral dialysis of DA in conscious rats but 6-OHDA was not detectible in the perfusates. Neurotoxic effects of these DA releasing drugs are therefore probably not due, as previously suggested, to 6-OHDA formation and its subsequent uptake into nerve terminals.

U2 - 10.1016/0014-2999(86)90011-7

DO - 10.1016/0014-2999(86)90011-7

M3 - Comment/Letter to the editor

SN - 0014-2999

VL - 132

SP - 65

EP - 69

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Failure to detect 6-hydroxydopamine in rat striatum after the dopamine releasing drugs dexamphetamine, methylamphetamine and MPTP

Abstract

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