Abstract
Background: beta(2)-Adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies.
Objective: We sought to apply family-based association methods to individual single nucleotide polymorphisms (SNPs) and haplotypes of SNPs in B2AR to define the relationship of these genetic variants to asthma-related phenotypes.
Methods: DNA samples were obtained from 707 Childhood Asthma Management Program participants, representing 650 sibships, as well as their parents. Genotyping was performed at 8 B2AR SNPs. Qualitative asthma-related phenotypes were analyzed with single SNPs and haplotypes by using TRANSMIT; quantitative asthma-related phenotypes were analyzed with the Family-Based Association Test.
Results: Several SNPs, including SNP -654 and SNP +46, demonstrated significant associations (P
Conclusion: B2AR variants are associated with spirometric values and bronchodilator responsiveness, but different regions of the gene provide evidence for association with these phenotypes.
| Original language | English |
|---|---|
| Pages (from-to) | 870-876 |
| Number of pages | 7 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 112 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov-2003 |
Keywords
- asthma
- genetics
- association analysis
- single nucleotide polymorphism
- haplotype
- bronchodilator
- GENOME-WIDE SEARCH
- GENETIC POLYMORPHISMS
- LINKAGE
- POPULATION
- HAPLOTYPES
- ALBUTEROL
- CHILDREN
- HYPERRESPONSIVENESS
- SUSCEPTIBILITY
- GENOTYPE