Family Distances as a Measure of Hidden Consanguinity: A Reappraisal

J Swaving; A Groenewegen; A Kamstra; G. J. Te Meerman; L.P. Ten Kate

doi:10.1159/000153967

Family Distances as a Measure of Hidden Consanguinity: A Reappraisal

J Swaving, A Groenewegen, A Kamstra, G. J. Te Meerman, L.P. Ten Kate^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We compared the family distances of patients with autosomal recessive disorders with those of a random control group and a matched control group. Only in the great-grandparental generation were weak-significant differences found. We also found that the family distances of persons with an urban origin were significantly larger than those of persons with a rural origin. In our study, family distance seems to be a more powerful measure of hidden consanguinity than the parental distance.

Original language	English
Pages (from-to)	12-16
Number of pages	5
Journal	Human heredity
Volume	41
Issue number	1
DOIs	https://doi.org/10.1159/000153967
Publication status	Published - 1991

Keywords

AUTOSOMAL RECESSIVE DISORDERS
CONSANGUINITY
FAMILY DISTANCES
GENEALOGY
GEOGRAPHIC-DISTRIBUTION
POPULATION-GENETICS
PROVINCE
FERRARA

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Family Distances as a Measure of Hidden Consanguinity
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title = "Family Distances as a Measure of Hidden Consanguinity: A Reappraisal",

abstract = "We compared the family distances of patients with autosomal recessive disorders with those of a random control group and a matched control group. Only in the great-grandparental generation were weak-significant differences found. We also found that the family distances of persons with an urban origin were significantly larger than those of persons with a rural origin. In our study, family distance seems to be a more powerful measure of hidden consanguinity than the parental distance.",

keywords = "AUTOSOMAL RECESSIVE DISORDERS, CONSANGUINITY, FAMILY DISTANCES, GENEALOGY, GEOGRAPHIC-DISTRIBUTION, POPULATION-GENETICS, PROVINCE, FERRARA",

author = "J Swaving and A Groenewegen and A Kamstra and {Te Meerman}, {G. J.} and {Ten Kate}, L.P.",

year = "1991",

doi = "10.1159/000153967",

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journal = "Human heredity",

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T1 - Family Distances as a Measure of Hidden Consanguinity

T2 - A Reappraisal

AU - Swaving, J

AU - Groenewegen, A

AU - Kamstra, A

AU - Te Meerman, G. J.

AU - Ten Kate, L.P.

PY - 1991

Y1 - 1991

N2 - We compared the family distances of patients with autosomal recessive disorders with those of a random control group and a matched control group. Only in the great-grandparental generation were weak-significant differences found. We also found that the family distances of persons with an urban origin were significantly larger than those of persons with a rural origin. In our study, family distance seems to be a more powerful measure of hidden consanguinity than the parental distance.

AB - We compared the family distances of patients with autosomal recessive disorders with those of a random control group and a matched control group. Only in the great-grandparental generation were weak-significant differences found. We also found that the family distances of persons with an urban origin were significantly larger than those of persons with a rural origin. In our study, family distance seems to be a more powerful measure of hidden consanguinity than the parental distance.

KW - AUTOSOMAL RECESSIVE DISORDERS

KW - CONSANGUINITY

KW - FAMILY DISTANCES

KW - GENEALOGY

KW - GEOGRAPHIC-DISTRIBUTION

KW - POPULATION-GENETICS

KW - PROVINCE

KW - FERRARA

U2 - 10.1159/000153967

DO - 10.1159/000153967

M3 - Article

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SP - 12

EP - 16

JO - Human heredity

JF - Human heredity

IS - 1

ER -

Family Distances as a Measure of Hidden Consanguinity: A Reappraisal

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Keywords

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