Farm exposures protect against allergen-induced Th2 activation, but induce neutrophilic lung inflammation. RAW 264.7 cells were differentiated into MHCIIhi, CD206hi and IL10+ phenotypes and cultured with farm dust extract. Farm dust exposure inhibited CD206hi and induced IL-10+ macrophages, suggesting a role for macrophages on the protective effect of farm exposures.
|Title of host publication
|Farming exposure and asthma phenotypes in mice and men
|Place of Publication
|Number of pages
|Published - 2015