Farm dust directs phenotype-specific macrophage activation which may contribute to protection against Th2-related disorders

Patricia Gonçalves Dias Pereira, Christina Draijer, T.R. Borg, Marjan Luinge, Willem Timens, I.M. Wouters, Barbro Melgert, Machteld Hylkema

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

4 Downloads (Pure)

Abstract

Farm exposures protect against allergen-induced Th2 activation, but induce neutrophilic lung inflammation. RAW 264.7 cells were differentiated into MHCIIhi, CD206hi and IL10+ phenotypes and cultured with farm dust extract. Farm dust exposure inhibited CD206hi and induced IL-10+ macrophages, suggesting a role for macrophages on the protective effect of farm exposures.
Original languageEnglish
Title of host publicationFarming exposure and asthma phenotypes in mice and men
Place of PublicationGroningen
PublisherRijksuniversiteit Groningen
Chapter7
Pages139-147
Number of pages9
ISBN (Print)978-94-6299-0791
Publication statusPublished - 2015

Cite this