Farm dust directs phenotype-specific macrophage activation which may contribute to protection against Th2-related disorders

Patricia Gonçalves Dias Pereira; Christina Draijer; T.R. Borg; Marjan Luinge; Willem Timens; I.M. Wouters; Barbro Melgert; Machteld Hylkema

Farm dust directs phenotype-specific macrophage activation which may contribute to protection against Th2-related disorders

Patricia Gonçalves Dias Pereira, Christina Draijer, T.R. Borg, Marjan Luinge, Willem Timens, I.M. Wouters, Barbro Melgert, Machteld Hylkema

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Abstract

Farm exposures protect against allergen-induced Th2 activation, but induce neutrophilic lung inflammation. RAW 264.7 cells were differentiated into MHCIIhi, CD206hi and IL10+ phenotypes and cultured with farm dust extract. Farm dust exposure inhibited CD206hi and induced IL-10+ macrophages, suggesting a role for macrophages on the protective effect of farm exposures.

Original language	English
Title of host publication	Farming exposure and asthma phenotypes in mice and men
Place of Publication	Groningen
Publisher	Rijksuniversiteit Groningen
Chapter	7
Pages	139-147
Number of pages	9
ISBN (Print)	978-94-6299-0791
Publication status	Published - 2015

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Farm dust directs phenotype-specific macrophage activationFinal publisher's version, 967 KBLicence: Taverne

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@inbook{dd452adca682423a87515d225062f8be,

title = "Farm dust directs phenotype-specific macrophage activation which may contribute to protection against Th2-related disorders",

abstract = "Farm exposures protect against allergen-induced Th2 activation, but induce neutrophilic lung inflammation. RAW 264.7 cells were differentiated into MHCIIhi, CD206hi and IL10+ phenotypes and cultured with farm dust extract. Farm dust exposure inhibited CD206hi and induced IL-10+ macrophages, suggesting a role for macrophages on the protective effect of farm exposures. ",

author = "{Gon{\c c}alves Dias Pereira}, Patricia and Christina Draijer and T.R. Borg and Marjan Luinge and Willem Timens and I.M. Wouters and Barbro Melgert and Machteld Hylkema",

year = "2015",

language = "English",

isbn = "978-94-6299-0791",

pages = "139--147",

booktitle = "Farming exposure and asthma phenotypes in mice and men",

publisher = "Rijksuniversiteit Groningen",

}

Farm dust directs phenotype-specific macrophage activation which may contribute to protection against Th2-related disorders. / Gonçalves Dias Pereira, Patricia; Draijer, Christina; Borg, T.R. et al.
Farming exposure and asthma phenotypes in mice and men. Groningen: Rijksuniversiteit Groningen, 2015. p. 139-147.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

TY - CHAP

T1 - Farm dust directs phenotype-specific macrophage activation which may contribute to protection against Th2-related disorders

AU - Gonçalves Dias Pereira, Patricia

AU - Draijer, Christina

AU - Borg, T.R.

AU - Luinge, Marjan

AU - Timens, Willem

AU - Wouters, I.M.

AU - Melgert, Barbro

AU - Hylkema, Machteld

PY - 2015

Y1 - 2015

N2 - Farm exposures protect against allergen-induced Th2 activation, but induce neutrophilic lung inflammation. RAW 264.7 cells were differentiated into MHCIIhi, CD206hi and IL10+ phenotypes and cultured with farm dust extract. Farm dust exposure inhibited CD206hi and induced IL-10+ macrophages, suggesting a role for macrophages on the protective effect of farm exposures.

AB - Farm exposures protect against allergen-induced Th2 activation, but induce neutrophilic lung inflammation. RAW 264.7 cells were differentiated into MHCIIhi, CD206hi and IL10+ phenotypes and cultured with farm dust extract. Farm dust exposure inhibited CD206hi and induced IL-10+ macrophages, suggesting a role for macrophages on the protective effect of farm exposures.

M3 - Chapter

SN - 978-94-6299-0791

SP - 139

EP - 147

BT - Farming exposure and asthma phenotypes in mice and men

PB - Rijksuniversiteit Groningen

CY - Groningen

ER -

Farm dust directs phenotype-specific macrophage activation which may contribute to protection against Th2-related disorders

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