Abstract
We describe the influence of developmental, demographic and clinical determinants on caffeine pharmacokinetics in a multi-ethnic hospital population of 104 very premature infants. We also report on the incidence of apnoeas, bradycardias and desaturations and their relationship with measured serum caffeine levels. Caffeine pharmacokinetics/pharmacodynamics was studied retrospectively, utilizing therapeutic drug monitoring data from the first six weeks of neonatal life and data from the medical records. Retrospective analysis of therapeutic drug monitoring data can be utilized to make an estimate of the individual pharmacokinetic parameters based on population pharmacokinetics. With this technique, we were able to identify subgroups with deviating pharmacokinetics. The retrospective approach was not adequate to study pharmacodynamics, due to underreporting in the medical records.
| Translated title of the contribution | On the way to dosage refinement. Pharmacokinetics of caffeine in premature infants with apnoea |
|---|---|
| Original language | Dutch |
| Pages (from-to) | 1021-1027 |
| Number of pages | 7 |
| Journal | Pharmaceutisch Weekblad |
| Volume | 137 |
| Issue number | 29 |
| Publication status | Published - 19-Jul-2002 |
Keywords
- caffeine
- apnea
- article
- bradycardia
- controlled study
- demography
- drug blood level
- fatty acid desaturation
- human
- incidence
- infant
- major clinical study
- medical record
- newborn
- patient monitoring
- prematurity