Farmacotherapie bij cystiche fibrosse: Slikken zonder verblikken

Translated title of the contribution: Swallowing without blanching. Pharmacotherapy of cystic fibrosis

Paul P.H. Le Brun, Daan J. Touw, Harry G.M. Heijerman

Research output: Contribution to journalSpecial issue editingAcademicpeer-review


Drug therapy in cystic fibrosis is focused on pulmonary infection and inflammation, intestinal obstruction and the substitution of pancreas enzymes. Most morbidity and mortality arises from the pulmonary infection and subsequent tissue destruction and deterioration of lung function. Antibiotic treatment is the mainstay of therapy. Nebulised antibiotics improve lung function and the incidence of acute exacerbations is reduced in patients chronically infected with Pseudomonas. Macrolides play a special role probably due to an antiinflammatory effect. Inhalation of rhDNAse improves lung function and decreases deterioration of lung function. New therapeutics directed at the CFTR defect are not yet available. Pharmacokinetics in CF patients may differ from those in healthy volunteers, probably due to differences in body composition.
Translated title of the contributionSwallowing without blanching. Pharmacotherapy of cystic fibrosis
Original languageDutch
Pages (from-to)803-809
Number of pages7
JournalPharmaceutisch Weekblad
Issue number23
Publication statusPublished - 6-Jun-2003


  • amikacin
  • aminoglycoside antibiotic agent
  • amoxicillin
  • amoxicillin plus clavulanic acid
  • antibiotic agent
  • azlocillin
  • aztreonam
  • beta lactam antibiotic
  • cefotaxime
  • ceftazidime
  • cefuroxime
  • cilastatin plus imipenem
  • ciprofloxacin
  • deoxyribonuclease
  • flucloxacillin
  • gentamicin
  • macrolide
  • meropenem
  • mucolytic agent
  • netilmicin
  • ofloxacin
  • pancreas enzyme
  • piperacillin
  • piperacillin plus tazobactam
  • quinoline derived antiinfective agent
  • ticarcillin
  • timentin
  • tobramycin
  • cystic fibrosis transmembrane conductance regulator
  • unindexed drug
  • antibiotic prophylaxis
  • antibiotic therapy
  • antiinflammatory activity
  • body composition
  • cause of death
  • cystic fibrosis
  • disease exacerbation
  • drug effect
  • drug indication
  • human
  • incidence
  • intestine obstruction
  • lung function
  • lung infection
  • morbidity
  • mortality
  • nebulization
  • pneumonia
  • Pseudomonas
  • short survey
  • swallowing
  • tissue injury

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