Fatal Attraction: Interactions between antigen-presenting cells and islets of Langerhans in the pathogenesis of autoimmune diabetes

Research output: ThesisThesis fully external

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In this thesis, the question is approached whether abnormalities in the islets of Langerhans, in addition to abnormalities in the immune system, are involved in the development of autoimmune diabetes in NOD mice. We found several islet abnormalities, always accompanied by an inflammatory infiltrate. Thus, intrinsic islet abnormalities may indeed play a role in the etiology of NOD autoimmune diabetes. Furthermore, we showed that infiltrating leukocytes can cause islet abnormalities. Thus, a complex cross-talk between antigen-presenting cells and islets exists during development of autoimmune diabetes in NOD mice. A similar interaction may be important in the development of type 1 diabetes in humans.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Erasmus MC, Erasmus University Rotterdam, Dept Immunol
  • van Ewijk, Willem, Supervisor, External person
  • Drexhage, Hemmo A., Supervisor, External person
  • Leenen, Pieter J.M., Co-supervisor, External person
  • Homo-Delarche, Françoise, Advisor, External person
  • Büller, Hans A., Assessment committee, External person
  • van der Kwast, Theo, Assessment committee, External person
  • Roep, Bart O., Assessment committee, External person
  • McDevitt, Hugh, Opponent, External person
  • Pols, Huib, Opponent, External person
Award date7-Jun-2000
Place of Publication[S.l.]
Print ISBNs90-73436-52-4
Publication statusPublished - 7-Jun-2000
Externally publishedYes


  • Diabetes Mellitus, Type 1

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