Fatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient

Heleen Aardema, Jaap E Tulleken, Ries J M van den Biggelaar, Bert A Wolters, Corine M de Jager, Charles A B Boucher, Annelies Riezebos-Brilman

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2 Citations (Scopus)

Abstract

A 58-year-old man was submitted to our intensive care ward with respiratory failure due to pneumonitis. He had previously been treated for non-Hodgkin lymphoma by autologous stem cell transplantation, as a result of which bone marrow function was reduced. Further analysis showed infection with new influenza A(H1N1); typing revealed an oseltamivir-resistant subpopulation (H275Y). The patient was treated with oseltamivir and intravenously with zanamivir, but died of respiratory disease progression. This is the first published case of oseltamivir-resistant new influenza A(H1N1) infection in the Netherlands.

Translated title of the contributionFatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient
Original languageDutch
Pages (from-to)A1634
JournalNederlands Tijdschrift voor Geneeskunde
Volume154
Publication statusPublished - 2010

Keywords

  • Antiviral Agents
  • Drug Resistance, Viral
  • Fatal Outcome
  • Humans
  • Immunocompromised Host
  • Influenza A Virus, H1N1 Subtype
  • Influenza, Human
  • Male
  • Middle Aged
  • Oseltamivir
  • Pneumonia
  • Zanamivir

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