Fatigue in patients with systemic lupus erythematosus: the role of dehydroepiandrosterone sulphate

C. L. Overman; A. Hartkamp; E. R. Bossema; M. Bijl; G. L. R. Godaert; J. W. J. Bijlsma; R. H. W. M. Derksen; R. Geenen

doi:10.1177/0961203312459105

Fatigue in patients with systemic lupus erythematosus: the role of dehydroepiandrosterone sulphate

C. L. Overman^*, A. Hartkamp, E. R. Bossema, M. Bijl, G. L. R. Godaert, J. W. J. Bijlsma, R. H. W. M. Derksen, R. Geenen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Fatigue is a major problem in systemic lupus erythematosus (SLE), but the physiological substrate of this fatigue is largely unclear. To examine if low levels of dehydroepiandrosterone (DHEA) and its sulphate DHEAS play a role in SLE fatigue, we compared: 1) DHEAS levels and fatigue between 60 female patients with SLE with low disease activity (31 using, 29 not using prednisone) and 60 age-matched healthy women, and 2) fatigue between patients with SLE with low and normal DHEAS levels. Serum DHEAS levels were determined with an Advantage Chemiluminescense System. The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue. Patients were more fatigued (p = 0.39). Patients with low DHEAS levels not using prednisone reported less fatigue than those with normal DHEAS levels (p

Original language	English
Pages (from-to)	1515-1521
Number of pages	7
Journal	Lupus
Volume	21
Issue number	14
DOIs	https://doi.org/10.1177/0961203312459105
Publication status	Published - Dec-2012

Keywords

Systemic lupus erythematosus
dehydroepiandrosterone
fatigue
prednisone
QUALITY-OF-LIFE
PLACEBO-CONTROLLED TRIAL
DISEASE-ACTIVITY
DOUBLE-BLIND
WOMEN
DEPRESSION
ASSOCIATIONS
STEROIDS
CRITERIA
HEALTH

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@article{70a8f586c25e44628c846957842261fd,

title = "Fatigue in patients with systemic lupus erythematosus: the role of dehydroepiandrosterone sulphate",

abstract = "Fatigue is a major problem in systemic lupus erythematosus (SLE), but the physiological substrate of this fatigue is largely unclear. To examine if low levels of dehydroepiandrosterone (DHEA) and its sulphate DHEAS play a role in SLE fatigue, we compared: 1) DHEAS levels and fatigue between 60 female patients with SLE with low disease activity (31 using, 29 not using prednisone) and 60 age-matched healthy women, and 2) fatigue between patients with SLE with low and normal DHEAS levels. Serum DHEAS levels were determined with an Advantage Chemiluminescense System. The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue. Patients were more fatigued (p = 0.39). Patients with low DHEAS levels not using prednisone reported less fatigue than those with normal DHEAS levels (p",

keywords = "Systemic lupus erythematosus, dehydroepiandrosterone, fatigue, prednisone, QUALITY-OF-LIFE, PLACEBO-CONTROLLED TRIAL, DISEASE-ACTIVITY, DOUBLE-BLIND, WOMEN, DEPRESSION, ASSOCIATIONS, STEROIDS, CRITERIA, HEALTH",

author = "Overman, {C. L.} and A. Hartkamp and Bossema, {E. R.} and M. Bijl and Godaert, {G. L. R.} and Bijlsma, {J. W. J.} and Derksen, {R. H. W. M.} and R. Geenen",

year = "2012",

month = dec,

doi = "10.1177/0961203312459105",

language = "English",

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pages = "1515--1521",

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TY - JOUR

T1 - Fatigue in patients with systemic lupus erythematosus

T2 - the role of dehydroepiandrosterone sulphate

AU - Overman, C. L.

AU - Hartkamp, A.

AU - Bossema, E. R.

AU - Bijl, M.

AU - Godaert, G. L. R.

AU - Bijlsma, J. W. J.

AU - Derksen, R. H. W. M.

AU - Geenen, R.

PY - 2012/12

Y1 - 2012/12

N2 - Fatigue is a major problem in systemic lupus erythematosus (SLE), but the physiological substrate of this fatigue is largely unclear. To examine if low levels of dehydroepiandrosterone (DHEA) and its sulphate DHEAS play a role in SLE fatigue, we compared: 1) DHEAS levels and fatigue between 60 female patients with SLE with low disease activity (31 using, 29 not using prednisone) and 60 age-matched healthy women, and 2) fatigue between patients with SLE with low and normal DHEAS levels. Serum DHEAS levels were determined with an Advantage Chemiluminescense System. The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue. Patients were more fatigued (p = 0.39). Patients with low DHEAS levels not using prednisone reported less fatigue than those with normal DHEAS levels (p

AB - Fatigue is a major problem in systemic lupus erythematosus (SLE), but the physiological substrate of this fatigue is largely unclear. To examine if low levels of dehydroepiandrosterone (DHEA) and its sulphate DHEAS play a role in SLE fatigue, we compared: 1) DHEAS levels and fatigue between 60 female patients with SLE with low disease activity (31 using, 29 not using prednisone) and 60 age-matched healthy women, and 2) fatigue between patients with SLE with low and normal DHEAS levels. Serum DHEAS levels were determined with an Advantage Chemiluminescense System. The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue. Patients were more fatigued (p = 0.39). Patients with low DHEAS levels not using prednisone reported less fatigue than those with normal DHEAS levels (p

KW - Systemic lupus erythematosus

KW - dehydroepiandrosterone

KW - fatigue

KW - prednisone

KW - QUALITY-OF-LIFE

KW - PLACEBO-CONTROLLED TRIAL

KW - DISEASE-ACTIVITY

KW - DOUBLE-BLIND

KW - WOMEN

KW - DEPRESSION

KW - ASSOCIATIONS

KW - STEROIDS

KW - CRITERIA

KW - HEALTH

U2 - 10.1177/0961203312459105

DO - 10.1177/0961203312459105

M3 - Article

SN - 0961-2033

VL - 21

SP - 1515

EP - 1521

JO - Lupus

JF - Lupus

IS - 14

ER -

Fatigue in patients with systemic lupus erythematosus: the role of dehydroepiandrosterone sulphate

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Keywords

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