Abstract
BACKGROUND AND PURPOSE: Previously, we showed a good correlation between pathology and an automatically generated PET-contour in rectal cancer. This study analyzed the effect of the use of PET-CT scan on the interobserver variation in GTV definition in rectal cancer and the influence of PET-CT on treatment volumes.
MATERIALS AND METHODS: Forty two patients diagnosed with rectal cancer underwent an FDG-PET-CT for radiotherapy planning. An automatic contour was created on PET-scan using the source-to-background ratio. The GTV was delineated by 5 observers in 3 rounds: using CT and MRI, using CT, MRI and PET and using CT, MRI and PET auto-contour. GTV volumes were compared and concordance indices (CI) were calculated. Since the GTV is only a small portion of the treatment volume in rectal cancer, a separate analysis was performed to evaluate the influence of PET on the definition of the CTV used in daily clinical practice and the caudal extension of the treatment volumes.
RESULTS: GTV volumes based on PET were significantly smaller. CIs increased significantly using PET and the best interobserver agreement was observed using PET auto-contours. Furthermore, we found that in up to 29% of patients the CTV based on PET extended outside the CTV used in clinical practice. The caudal border of the treatment volume can be tailored using PET-scan in low seated tumors. Influence of PET on the position of the caudal border was most pronounced in high seated tumors.
CONCLUSION: PET-CT increases the interobserver agreement in the GTV definition in rectal cancer, helps to avoid geographical misses and allows tailoring the caudal border of the treatment volume.
Original language | English |
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Pages (from-to) | 371-6 |
Number of pages | 6 |
Journal | Radiotherapy and Oncology |
Volume | 102 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar-2012 |
Externally published | Yes |
Keywords
- Fluorodeoxyglucose F18
- Humans
- Multimodal Imaging/methods
- Observer Variation
- Positron-Emission Tomography
- Radiopharmaceuticals
- Radiotherapy Planning, Computer-Assisted
- Rectal Neoplasms/diagnostic imaging
- Tomography, X-Ray Computed