Feasibility and accuracy of tissue characterization with dual source computed tomography

Joanne K. Van Abbema, Arjen Van der Schaaf, Wisnu Kristanto, Jaap M. Groen, Marcel J. W. Greuter*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

PURPOSE: To evaluate the feasibility and accuracy of a model for tissue characterization with dual source computed tomography (DSCT).

METHODS AND MATERIALS: A model for tissue characterization in CT was used with a parameterization of linear attenuation coefficients. Sixteen chemical substances with effective atomic numbers between 5.21 and 13.08 and electron densities between 2.20 and 4.12 x10(23) electrons/cm(3) were scanned at energies of 80 and 140 kV on a DSCT. From the reconstructed dual energy data sets, effective atomic numbers and electron densities of the substances were calculated.

RESULTS: Our presented model using DSCT approximated the effective atomic numbers and effective electron densities of 16 substances very well. The measured effective atomic numbers deviated 3.4 ± 6.8% (R(2) = 0.994) from theoretical effective atomic numbers. In addition, measured effective electron densities deviated -0.6 ± 2.2% (R(2) = 0.999) from theoretical effective electron densities.

CONCLUSION: Effective atomic numbers and effective electron densities can be determined with a high accuracy with DSCT. Therefore the model can be of potential benefit for clinical applications of quantitative tissue characterization with DSCT.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalPhysica medica-European journal of medical physics
Volume28
Issue number1
DOIs
Publication statusPublished - Jan-2012

Keywords

  • Dual energy
  • Computed tomography
  • Tissue characterization
  • Electron density
  • Effective atomic number
  • ENERGY MULTIDETECTOR CT
  • CARLO DOSE CALCULATIONS
  • ELECTRON-DENSITY
  • PERFORMANCE EVALUATION
  • INITIAL-EXPERIENCE
  • SINGLE-ENERGY
  • ATOMIC-NUMBER
  • URIC-ACID
  • STONES
  • DIFFERENTIATION

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