Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)

Natalia Oiring de Castro Cezar; Ivan Aprahamian; Juliana Hotta; Marcos Paulo Braz de Oliveira; Danielle Chagas Pereira da Silva; Wildja de Lima Gomes; Bruna Anzolin Barreiros; Tamiris de Cassia Oliva Langelli; Larissa Pires de Andrade

doi:10.1016/j.exger.2021.111390

Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)

Natalia Oiring de Castro Cezar^*, Ivan Aprahamian, Juliana Hotta, Marcos Paulo Braz de Oliveira, Danielle Chagas Pereira da Silva, Wildja de Lima Gomes, Bruna Anzolin Barreiros, Tamiris de Cassia Oliva Langelli, Larissa Pires de Andrade

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objectives: There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was to investigate the effect of a home-based multimodal exercise program for older adults with AD (AD-HOMEX) on frailty.

Design: A parallel single-blind randomized controlled trial comparing a home-based exercise program and usual care.

Setting and participants: A home-based program in Brazil. Forty individuals aged 65 years or older with mild to moderate AD.

Methods: The intervention group (IG) participated in a 16-week protocol involving three 60-minute sessions per week of progressive individualized physical exercises supervised by a physical therapist. The participants in the control group (CG) maintained their usual care. Frailty was assessed using the FRAIL questionnaire, the Edmonton Frail Scale (EFS) and a subjective assessment by the evaluator (SAE) at baseline and follow-up. Per-protocol analysis was performed.

Results: Thirty-five participants completed the program (IG = 16; CG = 19). Frailty improved in the IG based on the EFS (P = .004) and FRAIL (P

Conclusions and implications: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.

Original language	English
Article number	111390
Pages (from-to)	1-8
Number of pages	8
Journal	Experimental Gerontology
Volume	150
DOIs	https://doi.org/10.1016/j.exger.2021.111390
Publication status	Published - 15-Jul-2021

Keywords

Physical activity
Exercise
Alzheimer's
Frailty
Home-based
Randomized controlled trial
COGNITIVE IMPAIRMENT
SOCIAL DESIRABILITY
DISEASE
INTERVENTION
PEOPLE
MILD
PROGRAM
PERFORMANCE
MOBILITY
BALANCE

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Feasibility of reducing frailty components in older adults with Alzheimer's dementia- a randomized controlled home-based exercise trial (AD-HOMEX)Final publisher's version, 1.86 MBLicence: Taverne

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Cezar, N. O. D. C., Aprahamian, I., Hotta, J., de Oliveira, M. P. B., da Silva, D. C. P., Gomes, W. D. L., Barreiros, B. A., Langelli, T. D. C. O., & Andrade, L. P. D. (2021). Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX). Experimental Gerontology, 150, 1-8. Article 111390. https://doi.org/10.1016/j.exger.2021.111390

@article{bd7cf53030e54f388016e8a5ce63da00,

title = "Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)",

abstract = "Objectives: There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was to investigate the effect of a home-based multimodal exercise program for older adults with AD (AD-HOMEX) on frailty.Design: A parallel single-blind randomized controlled trial comparing a home-based exercise program and usual care.Setting and participants: A home-based program in Brazil. Forty individuals aged 65 years or older with mild to moderate AD.Methods: The intervention group (IG) participated in a 16-week protocol involving three 60-minute sessions per week of progressive individualized physical exercises supervised by a physical therapist. The participants in the control group (CG) maintained their usual care. Frailty was assessed using the FRAIL questionnaire, the Edmonton Frail Scale (EFS) and a subjective assessment by the evaluator (SAE) at baseline and follow-up. Per-protocol analysis was performed.Results: Thirty-five participants completed the program (IG = 16; CG = 19). Frailty improved in the IG based on the EFS (P = .004) and FRAIL (PConclusions and implications: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.",

keywords = "Physical activity, Exercise, Alzheimer's, Frailty, Home-based, Randomized controlled trial, COGNITIVE IMPAIRMENT, SOCIAL DESIRABILITY, DISEASE, INTERVENTION, PEOPLE, MILD, PROGRAM, PERFORMANCE, MOBILITY, BALANCE",

author = "Cezar, {Natalia Oiring de Castro} and Ivan Aprahamian and Juliana Hotta and {de Oliveira}, {Marcos Paulo Braz} and {da Silva}, {Danielle Chagas Pereira} and Gomes, {Wildja de Lima} and Barreiros, {Bruna Anzolin} and Langelli, {Tamiris de Cassia Oliva} and Andrade, {Larissa Pires de}",

year = "2021",

month = jul,

day = "15",

doi = "10.1016/j.exger.2021.111390",

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Cezar, NODC, Aprahamian, I, Hotta, J, de Oliveira, MPB, da Silva, DCP, Gomes, WDL, Barreiros, BA, Langelli, TDCO & Andrade, LPD 2021, 'Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)', Experimental Gerontology, vol. 150, 111390, pp. 1-8. https://doi.org/10.1016/j.exger.2021.111390

Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX). / Cezar, Natalia Oiring de Castro; Aprahamian, Ivan; Hotta, Juliana et al.
In: Experimental Gerontology, Vol. 150, 111390, 15.07.2021, p. 1-8.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Feasibility of reducing frailty components in older adults with Alzheimer's dementia

T2 - a randomized controlled home-based exercise trial (AD-HOMEX)

AU - Cezar, Natalia Oiring de Castro

AU - Aprahamian, Ivan

AU - Hotta, Juliana

AU - de Oliveira, Marcos Paulo Braz

AU - da Silva, Danielle Chagas Pereira

AU - Gomes, Wildja de Lima

AU - Barreiros, Bruna Anzolin

AU - Langelli, Tamiris de Cassia Oliva

AU - Andrade, Larissa Pires de

PY - 2021/7/15

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N2 - Objectives: There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was to investigate the effect of a home-based multimodal exercise program for older adults with AD (AD-HOMEX) on frailty.Design: A parallel single-blind randomized controlled trial comparing a home-based exercise program and usual care.Setting and participants: A home-based program in Brazil. Forty individuals aged 65 years or older with mild to moderate AD.Methods: The intervention group (IG) participated in a 16-week protocol involving three 60-minute sessions per week of progressive individualized physical exercises supervised by a physical therapist. The participants in the control group (CG) maintained their usual care. Frailty was assessed using the FRAIL questionnaire, the Edmonton Frail Scale (EFS) and a subjective assessment by the evaluator (SAE) at baseline and follow-up. Per-protocol analysis was performed.Results: Thirty-five participants completed the program (IG = 16; CG = 19). Frailty improved in the IG based on the EFS (P = .004) and FRAIL (PConclusions and implications: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.

AB - Objectives: There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was to investigate the effect of a home-based multimodal exercise program for older adults with AD (AD-HOMEX) on frailty.Design: A parallel single-blind randomized controlled trial comparing a home-based exercise program and usual care.Setting and participants: A home-based program in Brazil. Forty individuals aged 65 years or older with mild to moderate AD.Methods: The intervention group (IG) participated in a 16-week protocol involving three 60-minute sessions per week of progressive individualized physical exercises supervised by a physical therapist. The participants in the control group (CG) maintained their usual care. Frailty was assessed using the FRAIL questionnaire, the Edmonton Frail Scale (EFS) and a subjective assessment by the evaluator (SAE) at baseline and follow-up. Per-protocol analysis was performed.Results: Thirty-five participants completed the program (IG = 16; CG = 19). Frailty improved in the IG based on the EFS (P = .004) and FRAIL (PConclusions and implications: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.

KW - Physical activity

KW - Exercise

KW - Alzheimer's

KW - Frailty

KW - Home-based

KW - Randomized controlled trial

KW - COGNITIVE IMPAIRMENT

KW - SOCIAL DESIRABILITY

KW - DISEASE

KW - INTERVENTION

KW - PEOPLE

KW - MILD

KW - PROGRAM

KW - PERFORMANCE

KW - MOBILITY

KW - BALANCE

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DO - 10.1016/j.exger.2021.111390

M3 - Article

SN - 0531-5565

VL - 150

SP - 1

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JO - Experimental Gerontology

JF - Experimental Gerontology

M1 - 111390

ER -

Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)

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Keywords

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