FIBRINOLYTIC-ACTIVITY IN THE ABDOMINAL-CAVITY OF RATS WITH FECAL PERITONITIS

Harry van Goor, JS de Graaf, WJ Sluiter, J van der Meer, VJJ Bom, RP Bleichrodt

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    Abstract

    Generalized peritonitis causes a reduction in abdominal fibrinolytic activity, resulting in persistence of intraabdominal fibrin with subsequent adhesion and abscess formation. The activities of tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI) were measured in the peritoneal fluid of rats with faecal peritonitis and correlated with the extent of peritoneal damage to determine the cause of decreased fibrinolysis. Activity of tPA was low during the study period of 8 days, but higher in rats with peritonitis than in controls. The activity of PAI in rats with peritonitis was significantly increased compared with that of controls during the whole study period (P

    Original languageEnglish
    Pages (from-to)1046-1049
    Number of pages4
    JournalBritish Journal of Surgery
    Volume81
    Issue number7
    Publication statusPublished - Jul-1994

    Keywords

    • GENERALIZED BACTERIAL PERITONITIS
    • ESCHERICHIA-COLI
    • PLASMINOGEN
    • INHIBITION
    • MECHANISM
    • ADHESIONS
    • DEBRIDEMENT

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