Field responses to perforant path stimulation in the rat dentate gyrus: Role of corticosterone and NMDA-receptor activation

CM Stienstra, MT van Diepen, M Joels*

*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Recent studies showed that corticosterone and NMDA receptor activation suppress cell turn-over in the dentate gyrus through a common pathway, the NMDA receptor acting downstream of the corticosteroids. The present data show that in the absence of corticosteroids but not of NMDA receptor activation synaptic responses of dentate cells are reduced. The reduced synaptic responsiveness in the absence of corticosterone is therefore probably not caused by changes in cell turn-over. (C) 2000 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalBrain Research
Volume854
Issue number1-2
DOIs
Publication statusPublished - 31-Jan-2000
Externally publishedYes

Keywords

  • dentate gyrus
  • rat
  • corticosterone
  • CEREBRAL GLUCOSE-UTILIZATION
  • GRANULE CELL DEGENERATION
  • SYNAPTIC TRANSMISSION
  • ADULT NEUROGENESIS
  • ADRENAL-STEROIDS
  • BLOOD-FLOW
  • DEATH
  • ANTAGONISTS
  • APOPTOSIS
  • INVIVO

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