Finding new edges: systems approaches to MTOR signaling

Alexander Martin Heberle, Ulrike Rehbein, Maria Rodríguez Peiris, Kathrin Thedieck*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    5 Citations (Scopus)
    61 Downloads (Pure)

    Abstract

    Cells have evolved highly intertwined kinase networks to finely tune cellular homeostasis to the environment. The network converging on the mechanistic target of rapamycin (MTOR) kinase constitutes a central hub that integrates metabolic signals and adapts cellular metabolism and functions to nutritional changes and stress. Feedforward and feedback loops, crosstalks and a plethora of modulators finely balance MTOR-driven anabolic and catabolic processes. This complexity renders it difficult - if not impossible - to intuitively decipher signaling dynamics and network topology. Over the last two decades, systems approaches have emerged as powerful tools to simulate signaling network dynamics and responses. In this review, we discuss the contribution of systems studies to the discovery of novel edges and modulators in the MTOR network in healthy cells and in disease.

    Original languageEnglish
    Pages (from-to)41-54
    Number of pages14
    JournalBiochemical Society Transactions
    Volume49
    Issue number1
    Early online date5-Feb-2021
    DOIs
    Publication statusPublished - Feb-2021

    Keywords

    • RICH AKT SUBSTRATE
    • MAMMALIAN TARGET
    • INSULIN-RESISTANCE
    • TUMOR-SUPPRESSOR
    • RAG GTPASES
    • PHOSPHOPROTEOME REVEALS
    • TSC1-TSC2 COMPLEX
    • BINDING PARTNER
    • KINASE-ACTIVITY
    • GENE-PRODUCTS

    Fingerprint

    Dive into the research topics of 'Finding new edges: systems approaches to MTOR signaling'. Together they form a unique fingerprint.

    Cite this