Abstract
A combination of Southern blot analysis on a panel of tumor-derived somatic cell hybrids and fluorescence in situ hybridization (FISH) techniques was used to map a series of DNA markers relative to the 1q21 breakpoint of the renal cell carcinoma (RCC)-associated (X;1)-(p11;q21) translocation. This breakpoint maps between several members of the S100 family which are clustered in the 1q21 region and a conserved region between man and mouse containing the markers SPTA1-CRP-APCS-FcER1A-ATP1A2-APOA2. The location of the breakpoint coincides with the transition of a region of synteny of human chromosome 1 with mouse chromosomes 3 and 1.
| Original language | English |
|---|---|
| Pages (from-to) | 16-21 |
| Number of pages | 6 |
| Journal | HUMAN GENETICS |
| Volume | 98 |
| Issue number | 1 |
| Publication status | Published - Jul-1996 |
Keywords
- CALCIUM-BINDING PROTEINS
- CHROMOSOMAL LOCALIZATION
- RENAL ADENOCARCINOMA
- CYSTIC-FIBROSIS
- ALPHA-CHAIN
- MOUSE
- GENE
- EXPRESSION
- CLASSIFICATION
- CYTOGENETICS