Fine mapping of the human renal oncocytoma-associated translocation (5;11)(q35;q13) breakpoint

RJ Sinke, T Dijkhuizen, B Janssen, DO Weghuis, G Merkx, E vandenBerg, E Schuuring, AM Meloni, B deJong, AG vanKessel

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Abstract

Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;11)(q35;q13) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;11)-positive renal oncocytomas and a panel of somatic cell hybrids derived from one of these tumors, in conjunction with fluorescence in situ hybridization (FISH) and Southern blot analysis. The breakpoint in chromosome band 11q13 could be located within a genomic interval of at maximum 400 Kb immediately centromeric to the BCL1 locus. (C) Elsevier Science Inc., 1997.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume96
Issue number2
Publication statusPublished - 15-Jul-1997

Keywords

  • GERM-CELL TUMORS
  • CHROMOSOME 11Q13 REGION
  • MOLECULAR CHARACTERIZATION
  • CYTOGENETIC ANALYSIS
  • MITOCHONDRIAL-DNA
  • CYCLIN D1
  • CARCINOMAS
  • MAP
  • CLASSIFICATION
  • IDENTIFICATION

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