Fluorene-Based Multicomponent Reactions

Xiaofang Lei, Maria Thomaidi, Giasemi K. Angeli, Alexander Dömling, Constantinos G. Neochoritis*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
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Fluorene and fluorenone are privileged structures with extensive utility in both materials science and drug discovery. Here, we describe syntheses of those moieties through isocyanide-based multicomponent reactions (IMCRs) and the incorporation of the products in diverse and complex derivatives that can be further utilized. We performed six different IMCRs, based on the dual functionality of 9-isocyano-9H-fluorene, and we describe 23 unprecedented adducts.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
Issue number2
Publication statusPublished - 1-Jan-2022


  • fluorene
  • fluorenone
  • isocyanofluorene
  • multicomponent reactions
  • spiro compounds
  • Ugi reaction

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