Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures

Kenneth M. Tichauer, Cody Rounds, Veronica C. Torres, Chengyue Li, Hang Nguyen, Thom S. Nijboer, Floris J. Voskuil, Jovan G. Brankov, Max J. H. Witjes

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

An increasing number of cancer surgery protocols are including sentinel lymph node biopsies on the day of resection to stage for non-palpable spread of cancer through tumor draining lymph nodes. The challenge is that often a tumor-positive node will make it necessary to perform an enhanced resection of the lymphatic network, and if lymph node processing is not completed within the timeframe of surgery, then patients may have to be called back for additional surgery or have to undergo amplified chemo or radiation therapy. Our group is working on a rapid lymph node staining and fluorescence tomography system that we call ADEPT to provide surgeons with lymph node biopsy results within 15 min. The aim is to minimize the number of callback surgery or amplified therapy procedures to minimize stress to patients and reduce health care costs. This work predicts, using Monte Carlo photon propagation modeling simulations, that ADEPT has the potential to yield greater than 95% accuracy in detecting the smallest amount of cancer considered clinically relevant withing 15 min of tissue processing and imaging.

Original languageEnglish
Title of host publicationMolecular-Guided Surgery
Subtitle of host publicationMolecules, Devices, and Applications IX
EditorsSylvain Gioux, Summer L. Gibbs, Brian W. Pogue
PublisherSPIE
ISBN (Electronic)9781510658271
DOIs
Publication statusPublished - 2023
EventMolecular-Guided Surgery: Molecules, Devices, and Applications IX 2023 - San Francisco, United States
Duration: 28-Jan-202329-Jan-2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12361
ISSN (Print)1605-7422

Conference

ConferenceMolecular-Guided Surgery: Molecules, Devices, and Applications IX 2023
Country/TerritoryUnited States
CitySan Francisco
Period28/01/202329/01/2023

Keywords

  • Fluorescence tomography
  • molecular imaging
  • Monte Carlo modeling
  • paired-agent imaging
  • sentinel lymph node biopsy

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