Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures

Kenneth M. Tichauer; Cody Rounds; Veronica C. Torres; Chengyue Li; Hang Nguyen; Thom S. Nijboer; Floris J. Voskuil; Jovan G. Brankov; Max J. H. Witjes

doi:10.1117/12.2654231

Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures

Kenneth M. Tichauer, Cody Rounds, Veronica C. Torres, Chengyue Li, Hang Nguyen, Thom S. Nijboer, Floris J. Voskuil, Jovan G. Brankov, Max J. H. Witjes

Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

An increasing number of cancer surgery protocols are including sentinel lymph node biopsies on the day of resection to stage for non-palpable spread of cancer through tumor draining lymph nodes. The challenge is that often a tumor-positive node will make it necessary to perform an enhanced resection of the lymphatic network, and if lymph node processing is not completed within the timeframe of surgery, then patients may have to be called back for additional surgery or have to undergo amplified chemo or radiation therapy. Our group is working on a rapid lymph node staining and fluorescence tomography system that we call ADEPT to provide surgeons with lymph node biopsy results within 15 min. The aim is to minimize the number of callback surgery or amplified therapy procedures to minimize stress to patients and reduce health care costs. This work predicts, using Monte Carlo photon propagation modeling simulations, that ADEPT has the potential to yield greater than 95% accuracy in detecting the smallest amount of cancer considered clinically relevant withing 15 min of tissue processing and imaging.

Original language	English
Title of host publication	Molecular-Guided Surgery
Subtitle of host publication	Molecules, Devices, and Applications IX
Editors	Sylvain Gioux, Summer L. Gibbs, Brian W. Pogue
Publisher	SPIE
ISBN (Electronic)	9781510658271
DOIs	https://doi.org/10.1117/12.2654231
Publication status	Published - 2023
Event	Molecular-Guided Surgery: Molecules, Devices, and Applications IX 2023 - San Francisco, United States Duration: 28-Jan-2023 → 29-Jan-2023

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12361
ISSN (Print)	1605-7422

Conference

Conference	Molecular-Guided Surgery: Molecules, Devices, and Applications IX 2023
Country/Territory	United States
City	San Francisco
Period	28/01/2023 → 29/01/2023

Keywords

Fluorescence tomography
molecular imaging
Monte Carlo modeling
paired-agent imaging
sentinel lymph node biopsy

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Tichauer, K. M., Rounds, C., Torres, V. C., Li, C., Nguyen, H., Nijboer, T. S., Voskuil, F. J., Brankov, J. G., & Witjes, M. J. H. (2023). Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures. In S. Gioux, S. L. Gibbs, & B. W. Pogue (Eds.), Molecular-Guided Surgery: Molecules, Devices, and Applications IX Article 123610C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12361). SPIE. https://doi.org/10.1117/12.2654231

Tichauer, Kenneth M. ; Rounds, Cody ; Torres, Veronica C. et al. / Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures. Molecular-Guided Surgery: Molecules, Devices, and Applications IX. editor / Sylvain Gioux ; Summer L. Gibbs ; Brian W. Pogue. SPIE, 2023. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{9317450c5735420092c585a736d6f5a9,

title = "Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures",

abstract = "An increasing number of cancer surgery protocols are including sentinel lymph node biopsies on the day of resection to stage for non-palpable spread of cancer through tumor draining lymph nodes. The challenge is that often a tumor-positive node will make it necessary to perform an enhanced resection of the lymphatic network, and if lymph node processing is not completed within the timeframe of surgery, then patients may have to be called back for additional surgery or have to undergo amplified chemo or radiation therapy. Our group is working on a rapid lymph node staining and fluorescence tomography system that we call ADEPT to provide surgeons with lymph node biopsy results within 15 min. The aim is to minimize the number of callback surgery or amplified therapy procedures to minimize stress to patients and reduce health care costs. This work predicts, using Monte Carlo photon propagation modeling simulations, that ADEPT has the potential to yield greater than 95% accuracy in detecting the smallest amount of cancer considered clinically relevant withing 15 min of tissue processing and imaging.",

keywords = "Fluorescence tomography, molecular imaging, Monte Carlo modeling, paired-agent imaging, sentinel lymph node biopsy",

author = "Tichauer, {Kenneth M.} and Cody Rounds and Torres, {Veronica C.} and Chengyue Li and Hang Nguyen and Nijboer, {Thom S.} and Voskuil, {Floris J.} and Brankov, {Jovan G.} and Witjes, {Max J. H.}",

note = "Funding Information: This work was funded by NSF CAREER Award (1653627) and the Nayar Prize at Illinois Tech. The human lymph nodes used for measuring typical node dimensions were provided by Jesse Dirksen, MD, Sanford Health, Sioux Falls, SD. Publisher Copyright: {\textcopyright} 2023 SPIE.; Molecular-Guided Surgery: Molecules, Devices, and Applications IX 2023 ; Conference date: 28-01-2023 Through 29-01-2023",

year = "2023",

doi = "10.1117/12.2654231",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Sylvain Gioux and Gibbs, {Summer L.} and Pogue, {Brian W.}",

booktitle = "Molecular-Guided Surgery",

}

Tichauer, KM, Rounds, C, Torres, VC, Li, C, Nguyen, H, Nijboer, TS , Voskuil, FJ, Brankov, JG & Witjes, MJH 2023, Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures. in S Gioux, SL Gibbs & BW Pogue (eds), Molecular-Guided Surgery: Molecules, Devices, and Applications IX., 123610C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12361, SPIE, Molecular-Guided Surgery: Molecules, Devices, and Applications IX 2023, San Francisco, United States, 28/01/2023. https://doi.org/10.1117/12.2654231

Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures. / Tichauer, Kenneth M.; Rounds, Cody; Torres, Veronica C. et al.
Molecular-Guided Surgery: Molecules, Devices, and Applications IX. ed. / Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue. SPIE, 2023. 123610C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12361).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures

AU - Tichauer, Kenneth M.

AU - Rounds, Cody

AU - Torres, Veronica C.

AU - Li, Chengyue

AU - Nguyen, Hang

AU - Nijboer, Thom S.

AU - Voskuil, Floris J.

AU - Brankov, Jovan G.

AU - Witjes, Max J. H.

N1 - Funding Information: This work was funded by NSF CAREER Award (1653627) and the Nayar Prize at Illinois Tech. The human lymph nodes used for measuring typical node dimensions were provided by Jesse Dirksen, MD, Sanford Health, Sioux Falls, SD. Publisher Copyright: © 2023 SPIE.

PY - 2023

Y1 - 2023

N2 - An increasing number of cancer surgery protocols are including sentinel lymph node biopsies on the day of resection to stage for non-palpable spread of cancer through tumor draining lymph nodes. The challenge is that often a tumor-positive node will make it necessary to perform an enhanced resection of the lymphatic network, and if lymph node processing is not completed within the timeframe of surgery, then patients may have to be called back for additional surgery or have to undergo amplified chemo or radiation therapy. Our group is working on a rapid lymph node staining and fluorescence tomography system that we call ADEPT to provide surgeons with lymph node biopsy results within 15 min. The aim is to minimize the number of callback surgery or amplified therapy procedures to minimize stress to patients and reduce health care costs. This work predicts, using Monte Carlo photon propagation modeling simulations, that ADEPT has the potential to yield greater than 95% accuracy in detecting the smallest amount of cancer considered clinically relevant withing 15 min of tissue processing and imaging.

AB - An increasing number of cancer surgery protocols are including sentinel lymph node biopsies on the day of resection to stage for non-palpable spread of cancer through tumor draining lymph nodes. The challenge is that often a tumor-positive node will make it necessary to perform an enhanced resection of the lymphatic network, and if lymph node processing is not completed within the timeframe of surgery, then patients may have to be called back for additional surgery or have to undergo amplified chemo or radiation therapy. Our group is working on a rapid lymph node staining and fluorescence tomography system that we call ADEPT to provide surgeons with lymph node biopsy results within 15 min. The aim is to minimize the number of callback surgery or amplified therapy procedures to minimize stress to patients and reduce health care costs. This work predicts, using Monte Carlo photon propagation modeling simulations, that ADEPT has the potential to yield greater than 95% accuracy in detecting the smallest amount of cancer considered clinically relevant withing 15 min of tissue processing and imaging.

KW - Fluorescence tomography

KW - molecular imaging

KW - Monte Carlo modeling

KW - paired-agent imaging

KW - sentinel lymph node biopsy

U2 - 10.1117/12.2654231

DO - 10.1117/12.2654231

M3 - Conference contribution

AN - SCOPUS:85159780555

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Molecular-Guided Surgery

A2 - Gioux, Sylvain

A2 - Gibbs, Summer L.

A2 - Pogue, Brian W.

PB - SPIE

T2 - Molecular-Guided Surgery: Molecules, Devices, and Applications IX 2023

Y2 - 28 January 2023 through 29 January 2023

ER -

Tichauer KM, Rounds C, Torres VC, Li C, Nguyen H, Nijboer TS et al. Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures. In Gioux S, Gibbs SL, Pogue BW, editors, Molecular-Guided Surgery: Molecules, Devices, and Applications IX. SPIE. 2023. 123610C. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2654231

Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures

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