Fluorescent Nanodiamonds as Free Radical Sensors in Aging Yeast Cells: a baker’s yeast response to small diamonds with great potential!

Kiran van der Laan

    Research output: ThesisThesis fully internal (DIV)

    1048 Downloads (Pure)

    Abstract

    With the double aging population of more people getting older, there is not only a scientific interest but also a societal relevance to better understand the process of aging. One of the mentioned causes of the functional decline in aging, is the accumulation of certain stress signals in our cells. But how exactly these signals are leading to these effects, is not yet known, because the stress signals are very hard to detect. That is why this research focused on a new detection method, by which we will be able to unravel the exact role of these stress signals in the aging process.
    For this purpose we use fluorescent nanodiamonds (FNDs) that beyond the sparkle, can also have some unique properties by which they can convert the stress signals in the cell into a (for a microscope) detectable signal. The diamonds can thus function as sensors for the stress signals. In this thesis several studies are presented, which all contribute to the development and applicability of this method. Important results are the successful internalization of the diamonds into the model system, the unchanged aging characteristics of the model and the lack of a stress response to our sensors. This opens the door for further research into these small diamonds with great potential!
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Schirhagl, Romana, Supervisor
    • Mzyk, Aldona, Co-supervisor
    Award date10-Feb-2020
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-2358-6
    Electronic ISBNs978-94-034-2357-9
    DOIs
    Publication statusPublished - 2020

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