Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues

Runrun Li, Thea A. Vedelaar, Alina Sigaeva, Yue Zhang, Kaiqi Wu, Hui Wang, Xixi Wu, Peter Olinga, Małgorzata K. Wlodarzyk-Biegun, Romana Schirhagl*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
40 Downloads (Pure)


Polymer nanoparticles are widely used in drug delivery and are also a potential concern due to the increased burden of nano- or microplastics in the environment. In order to use polymer nanoparticles safely and understand their mechanism of action, it is useful to know where within cells and tissues they end up. To this end, we labeled polymer nanoparticles with nanodiamond particles. More specifically, we have embedded nanodiamond particles in the polymer particles and characterized the composites. Compared to conventional fluorescent dyes, these labels have the advantage that nanodiamonds do not bleach or blink, thus allowing long-term imaging and tracking of polymer particles. We have demonstrated this principle both in cells and entire liver tissues.

Original languageEnglish
Pages (from-to)13046-13054
Number of pages9
JournalAnalytical Chemistry
Issue number35
Publication statusPublished - 5-Sept-2023


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