@article{e3de330683804db88f55d2a2a4ab2015,
title = "Fluoride Additive as a Simple Tool to Qualitatively Improve Performance of Nickel-Catalyzed Asymmetric Michael Addition of Malonates to Nitroolefins",
abstract = "Nowadays, design of the new chiral ligands for organometallic catalysts is often based on the step-by-step increase in their complexity to improve efficiency. Herein we describe that simple in situ addition of the fluoride source to the asymmetric organometallic catalyst can improve not only activity but also enantioselectivity. Bromide-nickel diimine complexes were found to catalyze asymmetric Michael addition in low yields and ee, but activation with fluoride leads to a significant improvement in catalyst performance. The developed approach was applied to prepare several enantioenriched GABA analogues.",
author = "Afanasyev, {Oleg I.} and Kliuev, {Fedor S.} and Tsygankov, {Alexey A.} and Nelyubina, {Yulia V.} and Evgenii Gutsul and Novikov, {Valentin V.} and Denis Chusov",
note = "Funding Information: This work was supported by Russian Science Foundation (grant no. 21-13-00157). Characterization of compounds using NMR, X-ray diffraction, and MS spectroscopy was performed using the equipment of Center for molecular composition studies of INEOS RAS with the financial support from Ministry of Science and Higher Education of the Russian Federation. Publisher Copyright: {\textcopyright} 2022 American Chemical Society. All rights reserved.",
year = "2022",
month = sep,
day = "16",
doi = "10.1021/acs.joc.2c01339",
language = "English",
volume = "87",
pages = "12182--12195",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "AMER CHEMICAL SOC INC",
number = "18",
}