Fluticasone propionate suppresses farm dust-induced airway hyperresponsiveness in mice but has no effect on lung neutrophils

Patricia Gonçalves Dias Pereira; Christina Draijer; Corry-Anke Brandsma; Laura Hesse; Marjan Luinge; Barbro Melgert; Willem Timens; I.M. Wouters; Machteld Hylkema

Fluticasone propionate suppresses farm dust-induced airway hyperresponsiveness in mice but has no effect on lung neutrophils

Patricia Gonçalves Dias Pereira, Christina Draijer, Corry-Anke Brandsma, Laura Hesse, Marjan Luinge, Barbro Melgert, Willem Timens, I.M. Wouters, Machteld Hylkema

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Abstract

Studies in men and mice have shown that farm dust exposure induces high levels of IL-17 in the airways, airway neutrophilia and airway hyperresponsiveness (AHR). In addition, it has been shown that agricultural workers have a high prevalence of respiratory symptoms related to nonallergic asthma. In nonallergic asthma, neutrophilic inflammation in the airways is predominant and this phenotype is associated with poor corticosteroid responsiveness. Since IL-17 is known to induce airway neutrophilia and has been associated with corticosteroid resistant airway inflammation, we hypothesized that farm dust exposure induces airway neutrophilia and AHR that are both resistant to corticosteroid treatment.

Original language	English
Title of host publication	Farming exposure and asthma phenotypes in mice and men
Place of Publication	Groningen
Publisher	Rijksuniversiteit Groningen
Chapter	4
Pages	77-97
Number of pages	21
ISBN (Print)	978-94-6299-0791
Publication status	Published - 2015

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Gonçalves Dias Pereira, P., Draijer, C., Brandsma, C.-A., Hesse, L., Luinge, M., Melgert, B., Timens, W., Wouters, I. M., & Hylkema, M. (2015). Fluticasone propionate suppresses farm dust-induced airway hyperresponsiveness in mice but has no effect on lung neutrophils. In Farming exposure and asthma phenotypes in mice and men (pp. 77-97). Rijksuniversiteit Groningen.

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title = "Fluticasone propionate suppresses farm dust-induced airway hyperresponsiveness in mice but has no effect on lung neutrophils",

abstract = "Studies in men and mice have shown that farm dust exposure induces high levels of IL-17 in the airways, airway neutrophilia and airway hyperresponsiveness (AHR). In addition, it has been shown that agricultural workers have a high prevalence of respiratory symptoms related to nonallergic asthma. In nonallergic asthma, neutrophilic inflammation in the airways is predominant and this phenotype is associated with poor corticosteroid responsiveness. Since IL-17 is known to induce airway neutrophilia and has been associated with corticosteroid resistant airway inflammation, we hypothesized that farm dust exposure induces airway neutrophilia and AHR that are both resistant to corticosteroid treatment. ",

author = "{Gon{\c c}alves Dias Pereira}, Patricia and Christina Draijer and Corry-Anke Brandsma and Laura Hesse and Marjan Luinge and Barbro Melgert and Willem Timens and I.M. Wouters and Machteld Hylkema",

year = "2015",

language = "English",

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pages = "77--97",

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Fluticasone propionate suppresses farm dust-induced airway hyperresponsiveness in mice but has no effect on lung neutrophils. / Gonçalves Dias Pereira, Patricia; Draijer, Christina; Brandsma, Corry-Anke et al.
Farming exposure and asthma phenotypes in mice and men. Groningen: Rijksuniversiteit Groningen, 2015. p. 77-97.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

TY - CHAP

T1 - Fluticasone propionate suppresses farm dust-induced airway hyperresponsiveness in mice but has no effect on lung neutrophils

AU - Gonçalves Dias Pereira, Patricia

AU - Draijer, Christina

AU - Brandsma, Corry-Anke

AU - Hesse, Laura

AU - Luinge, Marjan

AU - Melgert, Barbro

AU - Timens, Willem

AU - Wouters, I.M.

AU - Hylkema, Machteld

PY - 2015

Y1 - 2015

N2 - Studies in men and mice have shown that farm dust exposure induces high levels of IL-17 in the airways, airway neutrophilia and airway hyperresponsiveness (AHR). In addition, it has been shown that agricultural workers have a high prevalence of respiratory symptoms related to nonallergic asthma. In nonallergic asthma, neutrophilic inflammation in the airways is predominant and this phenotype is associated with poor corticosteroid responsiveness. Since IL-17 is known to induce airway neutrophilia and has been associated with corticosteroid resistant airway inflammation, we hypothesized that farm dust exposure induces airway neutrophilia and AHR that are both resistant to corticosteroid treatment.

AB - Studies in men and mice have shown that farm dust exposure induces high levels of IL-17 in the airways, airway neutrophilia and airway hyperresponsiveness (AHR). In addition, it has been shown that agricultural workers have a high prevalence of respiratory symptoms related to nonallergic asthma. In nonallergic asthma, neutrophilic inflammation in the airways is predominant and this phenotype is associated with poor corticosteroid responsiveness. Since IL-17 is known to induce airway neutrophilia and has been associated with corticosteroid resistant airway inflammation, we hypothesized that farm dust exposure induces airway neutrophilia and AHR that are both resistant to corticosteroid treatment.

M3 - Chapter

SN - 978-94-6299-0791

SP - 77

EP - 97

BT - Farming exposure and asthma phenotypes in mice and men

PB - Rijksuniversiteit Groningen

CY - Groningen

ER -

Fluticasone propionate suppresses farm dust-induced airway hyperresponsiveness in mice but has no effect on lung neutrophils

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