fMRI in translation: the challenges facing real-world applications

Stephan Schleim, Jonathan P. Roiser*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Functional neuroimaging has increased our understanding of human brain function tremendously and has become a standard tool in clinical and cognitive neuroscience research. We briefly review its methodological foundations and describe remaining challenges for translational research. The application of neuroimaging results to individual subjects, for example in predicting treatment response or determining the veracity of a statement, is limited by these challenges, in particular by the anatomical and statistical procedures commonly employed. We thus argue for sincere caution in the translation of functional neuroimaging to real-world applications.

    Original languageEnglish
    Article number63
    Number of pages7
    JournalFrontiers in Human Neuroscience
    Volume3
    DOIs
    Publication statusPublished - 23-Dec-2009

    Keywords

    • fMRI
    • translational research
    • clinical neuroscience
    • methodological limitations
    • real-world applications
    • BOLD FMRI
    • HEMODYNAMIC SIGNALS
    • NEURONAL-ACTIVITY
    • MAJOR DEPRESSION
    • VISUAL-CORTEX
    • BRAIN
    • NEUROSCIENCE
    • RESPONSES

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