For better or for worse: the role of Pim oncogenes in tumorigenesis

Martijn C. Nawijn, Andrej Alendar, Anton Berns*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

331 Citations (Scopus)

Abstract

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and epithelial origin. Pim genes encode serine/threonine kinases that have been shown to counteract the increased sensitivity to apoptosis induction that is associated with MYC-driven tumorigenesis. Recently, considerable progress has been made in characterizing the pathways of PIM-mediated survival signalling. Given the unique structure of their active site and the minimal phenotype of mice mutant for all Pim family members, these oncogenes might be promising targets for highly specific and selective drugs with favourable toxicity profiles. In this Review, we discuss the physiological functions and oncogenic activities of Pim kinases.

Original languageEnglish
Pages (from-to)23-34
Number of pages12
JournalNature reviews cancer
Volume11
Issue number1
DOIs
Publication statusPublished - Jan-2011

Keywords

  • B-CELL LYMPHOMA
  • ABERRANT SOMATIC HYPERMUTATION
  • PROSTATE-CANCER CELLS
  • BAD-MEDIATED APOPTOSIS
  • SERINE/THREONINE KINASE-ACTIVITY
  • CHRONIC LYMPHOCYTIC-LEUKEMIA
  • HUMAN PANCREATIC-CANCER
  • HUMAN T-CELLS
  • E-MU-MYC
  • C-MYC

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