Forkhead-box transcription factors and their role in the immune system

PJ Coffer; BMT Burgering

doi:10.1038/nri1488

Forkhead-box transcription factors and their role in the immune system

PJ Coffer^*, BMT Burgering

^*Corresponding author for this work

University of Groningen

Research output: Contribution to journal › Review article › peer-review

340 Citations (Scopus)

Abstract

It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening time, there has been an explosion in the identification and characterization of members of this family of proteins. Importantly, in the past few years, it has become clear that members of the FOX family have crucial roles in various aspects of immune regulation, from lymphocyte survival to thymic development. This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.

Original language	English
Pages (from-to)	889-899
Number of pages	11
Journal	Nature reviews immunology
Volume	4
Issue number	11
DOIs	https://doi.org/10.1038/nri1488
Publication status	Published - Nov-2004

Keywords

REGULATORY T-CELLS
NF-KAPPA-B
SCURFY SF MOUSE
FACTOR FOXO3A
CUTTING EDGE
IN-VIVO
PHOSPHOINOSITIDE 3-KINASE
DOWN-REGULATION
HELIX PROTEIN
CYCLE ARREST

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title = "Forkhead-box transcription factors and their role in the immune system",

abstract = "It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening time, there has been an explosion in the identification and characterization of members of this family of proteins. Importantly, in the past few years, it has become clear that members of the FOX family have crucial roles in various aspects of immune regulation, from lymphocyte survival to thymic development. This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.",

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author = "PJ Coffer and BMT Burgering",

year = "2004",

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doi = "10.1038/nri1488",

language = "English",

volume = "4",

pages = "889--899",

journal = "Nature reviews immunology",

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T1 - Forkhead-box transcription factors and their role in the immune system

AU - Coffer, PJ

AU - Burgering, BMT

PY - 2004/11

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N2 - It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening time, there has been an explosion in the identification and characterization of members of this family of proteins. Importantly, in the past few years, it has become clear that members of the FOX family have crucial roles in various aspects of immune regulation, from lymphocyte survival to thymic development. This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.

AB - It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening time, there has been an explosion in the identification and characterization of members of this family of proteins. Importantly, in the past few years, it has become clear that members of the FOX family have crucial roles in various aspects of immune regulation, from lymphocyte survival to thymic development. This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.

KW - REGULATORY T-CELLS

KW - NF-KAPPA-B

KW - SCURFY SF MOUSE

KW - FACTOR FOXO3A

KW - CUTTING EDGE

KW - IN-VIVO

KW - PHOSPHOINOSITIDE 3-KINASE

KW - DOWN-REGULATION

KW - HELIX PROTEIN

KW - CYCLE ARREST

U2 - 10.1038/nri1488

DO - 10.1038/nri1488

M3 - Review article

SN - 1474-1733

VL - 4

SP - 889

EP - 899

JO - Nature reviews immunology

JF - Nature reviews immunology

IS - 11

ER -

Forkhead-box transcription factors and their role in the immune system

Abstract

Keywords

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