TY - JOUR
T1 - Fruit and vegetable consumption and mortality
T2 - European prospective investigation into cancer and nutrition
AU - Leenders, Max
AU - Sluijs, Ivonne
AU - Ros, Martine M
AU - Boshuizen, Hendriek C
AU - Siersema, Peter D
AU - Ferrari, Pietro
AU - Weikert, Cornelia
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Boutron-Ruault, Marie-Christine
AU - Clavel-Chapelon, Françoise
AU - Nailler, Laura
AU - Teucher, Birgit
AU - Li, Kuanrong
AU - Boeing, Heiner
AU - Bergmann, Manuela M
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Trichopoulos, Dimitrios
AU - Palli, Domenico
AU - Pala, Valeria
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Peeters, Petra H M
AU - van Gils, Carla H
AU - Lund, Eiliv
AU - Engeset, Dagrun
AU - Redondo, Maria Luisa
AU - Agudo, Antonio
AU - Sánchez, Maria José
AU - Navarro, Carmen
AU - Ardanaz, Eva
AU - Sonestedt, Emily
AU - Ericson, Ulrika
AU - Nilsson, Lena Maria
AU - Khaw, Kay-Tee
AU - Wareham, Nicholas J
AU - Key, Timothy J
AU - Crowe, Francesca L
AU - Romieu, Isabelle
AU - Gunter, Marc J
AU - Gallo, Valentina
AU - Overvad, Kim
AU - Riboli, Elio
AU - Bueno-de-Mesquita, H Bas
PY - 2013/8/15
Y1 - 2013/8/15
N2 - In this study, the relation between fruit and vegetable consumption and mortality was investigated within the European Prospective Investigation Into Cancer and Nutrition. Survival analyses were performed, including 451,151 participants from 10 European countries, recruited between 1992 and 2000 and followed until 2010. Hazard ratios, rate advancement periods, and preventable proportions to respectively compare risk of death between quartiles of consumption, to estimate the period by which the risk of death was postponed among high consumers, and to estimate proportions of deaths that could be prevented if all participants would shift their consumption 1 quartile upward. Consumption of fruits and vegetables was inversely associated with all-cause mortality (for the highest quartile, hazard ratio = 0.90, 95% confidence interval (CI): 0.86, 0.94), with a rate advancement period of 1.12 years (95% CI: 0.70, 1.54), and with a preventable proportion of 2.95%. This association was driven mainly by cardiovascular disease mortality (for the highest quartile, hazard ratio = 0.85, 95% CI: 0.77, 0.93). Stronger inverse associations were observed for participants with high alcohol consumption or high body mass index and suggested in smokers. Inverse associations were stronger for raw than for cooked vegetable consumption. These results support the evidence that fruit and vegetable consumption is associated with a lower risk of death.
AB - In this study, the relation between fruit and vegetable consumption and mortality was investigated within the European Prospective Investigation Into Cancer and Nutrition. Survival analyses were performed, including 451,151 participants from 10 European countries, recruited between 1992 and 2000 and followed until 2010. Hazard ratios, rate advancement periods, and preventable proportions to respectively compare risk of death between quartiles of consumption, to estimate the period by which the risk of death was postponed among high consumers, and to estimate proportions of deaths that could be prevented if all participants would shift their consumption 1 quartile upward. Consumption of fruits and vegetables was inversely associated with all-cause mortality (for the highest quartile, hazard ratio = 0.90, 95% confidence interval (CI): 0.86, 0.94), with a rate advancement period of 1.12 years (95% CI: 0.70, 1.54), and with a preventable proportion of 2.95%. This association was driven mainly by cardiovascular disease mortality (for the highest quartile, hazard ratio = 0.85, 95% CI: 0.77, 0.93). Stronger inverse associations were observed for participants with high alcohol consumption or high body mass index and suggested in smokers. Inverse associations were stronger for raw than for cooked vegetable consumption. These results support the evidence that fruit and vegetable consumption is associated with a lower risk of death.
KW - Adult
KW - Aged
KW - Cause of Death
KW - Diet Surveys/statistics & numerical data
KW - Europe/epidemiology
KW - Female
KW - Fruit
KW - Humans
KW - Male
KW - Middle Aged
KW - Neoplasms/mortality
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Survival Analysis
KW - Vegetables
U2 - 10.1093/aje/kwt006
DO - 10.1093/aje/kwt006
M3 - Article
C2 - 23599238
SN - 0002-9262
VL - 178
SP - 590
EP - 602
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 4
ER -