Functionality of Sortase A in Lactococcus lactis

Yakhya Dieye, Virginie Oxaran, Florence Ledue-Clier, Walid Alkhalaf, Girbe Buist, Vincent Juillard, Chang Won Lee, Jean-Christophe Piard*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Abstract

Lactococcus lactis IL1403 harbors a putative sortase A (SrtA) and 11 putative sortase substrates that carry the canonical LPXTG signature of such substrates. We report here on the functionality of SrtA to anchor five LPXTG substrates to the cell wall, thus suggesting that SrtA is the housekeeping sortase in L. lactis IL1403.

Original languageEnglish
Pages (from-to)7332-7337
Number of pages6
JournalApplied and environmental microbiology
Volume76
Issue number21
DOIs
Publication statusPublished - Nov-2010

Keywords

  • GRAM-POSITIVE BACTERIA
  • CELL-WALL
  • STREPTOCOCCUS-PYOGENES
  • SURFACE-PROTEINS
  • ACID BACTERIA
  • BACILLUS-SUBTILIS
  • BINDING DOMAIN
  • SUBSP LACTIS
  • E7 ANTIGEN
  • GENE

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