Abstract
Calixspherands, like 1, form kinetically stable complexes with alkali metal cations. For practical in vivo applications coupling of these complexes with carrier molecules is mandatory, Therefore, a general method for the synthesis of functionalized calixspherand 17 was developed starting from functionalized m-terphenyl 10 and p-tert-butylcalix[4]arene (14). The functionalized m-terphenyl was synthesized by a Suzuki-cross-coupling reaction. Functionalized calixspherand 17 has been coupled to a low molecular weight protein.
| Original language | English |
|---|---|
| Pages (from-to) | 972-976 |
| Number of pages | 5 |
| Journal | Journal of Organic Chemistry |
| Volume | 59 |
| Issue number | 5 |
| Publication status | Published - 11-Mar-1994 |
Keywords
- MOLECULAR-WEIGHT PROTEINS
- HOST GUEST COMPLEXATION
- CALIX<4>ARENES
- HEMISPHERANDS
- CATIONS
- ACID